The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo

BMC Complementary and Alternative Medicine
Jin Mo KuSeong-Gyu Ko

Abstract

Jawoongo is an herbal mixture used in traditional medicine to treat skin diseases. This study aimed to investigate whether Jawoongo ameliorates Atopic dermatitis (AD)-like pathology in mice and to understand its underlying cellular mechanisms. AD was induced by 2, 4-Dinitrocholrlbenzene (DNCB) in BALB/c mice. Treatment with Jawoongo was assessed to study the effect of Jawoongo on AD in mice. Histological Analysis, blood analysis, RT-PCR, western blot analysis, ELISA assay and cell viability assay were performed to verify the inhibitory effect of Jawoongo on AD in mice. We found that application of Jawoongo in an ointment form on AD-like skin lesions on DNCB-exposed BALB/c mice reduced skin thickness and ameliorated skin infiltration with inflammatory cells, mast cells and CD4+ cells. The ointment also reduced the mRNA levels of IL-2, IL-4, IL-13 and TNF-α in the sensitized skin. Leukocyte counts and the levels of IgE, IL-6, IL-10 and IL-12 were decreased in the blood of the DNCB-treated mice. Furthermore, studies on cultured cells demonstrated that Jawoongo exhibits anti-inflammatory activities, including the suppression of proinflammatory cytokine expression, nitric oxide (NO) production, and inflammation-associated molecule l...Continue Reading

References

Sep 1, 1986·The Journal of Investigative Dermatology·C A HoldenJ M Hanifin
Apr 26, 2000·Laboratory Animals·J Weiss, F Zimmermann
Jun 5, 2003·Clinics in Dermatology·Nordwig S Tomi, Thomas A Luger
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul D RennertJoseph V Bonventre
Nov 28, 2006·The Journal of Allergy and Clinical Immunology·Massimo TriggianiGianni Marone
Mar 21, 2007·Chemical Immunology and Allergy·Bernhard HomeyAntti Lauerma
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yeping CaiDianne C Webb
May 20, 2009·Biochemical and Biophysical Research Communications·Hyun Jung MinEun Sook Hwang
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sang Kyun ParkHak Sun Yu
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naiqian NiuLauren Cohn
Jul 29, 2009·Respiratory Physiology & Neurobiology·Zhijun JieStephen Holgate
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masayuki KitajimaToshinori Nakayama
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulaganathan MabalirajanBalaram Ghosh
Dec 18, 2009·European Journal of Immunology·Mie ToriiTakuma Kato
Jun 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aurore DuboisVéronique Flamand
Aug 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soheila ShirinbakMartijn C Nawijn
Sep 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerard E KaikoPaul S Foster
Dec 21, 2010·Phytotherapy Research : PTR·Seung Hwa SonWon-Yoon Chung
Oct 14, 2011·Journal of Clinical & Cellular Immunology·Eric B Brandt, Umasundari Sivaprasad
Mar 1, 2012·Journal of Cancer Research and Clinical Oncology·Enas A HamedDoaa W Maximous
Mar 2, 2012·Urologia Internationalis·T QayyumJ Edwards
Mar 7, 2012·Free Radical Biology & Medicine·Joydeb Kumar Kundu, Young-Joon Surh
Mar 14, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine M AlfanoRachel Ballard-Barbash
Mar 31, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Oleksandr N KryvenkoBenjamin A Rybicki
Sep 12, 2014·Bioscience, Biotechnology, and Biochemistry·Sae-Jin ParkTack-Joong Kim
Oct 30, 2015·Annals of Dermatology·Hye One KimChun Wook Park
Jul 29, 2016·PloS One·Jernej ZormanIva Hafner-Bratkovič

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Methods Mentioned

BETA
ELISA
electrophoresis
PMA

Software Mentioned

PRISM
Chemstation
GraphPad

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