The prevention of anaphylactoid reactions to iodinated radiological contrast media: a systematic review.

BMC Medical Imaging
Anthony DelaneyM Fisher

Abstract

Anaphylactoid reactions to iodinated contrast media are relatively common and potentially life threatening. Opinion is divided as to the utility of medications for preventing these reactions. We performed a systematic review to assess regimes for the prevention of anaphylactoid reactions to iodinated contrast media. Searches for studies were conducted in the Medline, EMBASE, CINAHL and CENTRAL databases. Bibliographies of included studies and review articles were examined and experts were contacted. Randomised clinical trials that examined agents given prior to iodinated contrast material for the prevention of anaphylactoid reactions were included in the review. The validity of the included studies was examined using a component approach. Six studies met the inclusion criteria, but only one of these fulfilled all of the validity criteria. There were four studies that examined the use of H1 antihistamines, each was used to prevent anaphylactoid reactions to ionic contrast. The random effects pooled relative risk demonstrated a significant reduction in the overall rate of anaphylactoid reactions (RR = 0.4, 95% CI 0.18-0.9, p = 0.027). There were insufficient studies to produce a pooled statistic for the use of corticosteroids, ho...Continue Reading

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Citations

Oct 5, 2011·Clinical & Developmental Immunology·Michael D Benson
Dec 19, 2017·Aesthetic Surgery Journal·Erica L BartlettNorman H Rappaport
Oct 27, 2015·The Korean Journal of Pain·Sang Hyun LeeByeong Mun Hwang
Sep 28, 2013·Expert Review of Clinical Immunology·Allison Worth, Aziz Sheikh
Apr 19, 2019·Investigative Radiology·Young Joo SuhWhal Lee
Jun 8, 2013·Current Opinion in Allergy and Clinical Immunology·Enrique GómezMaria J Torres

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