The prevention of delirium in elderly with obstructive sleep apnea (PODESA) study: protocol for a multi-centre prospective randomized, controlled trial

BMC Anesthesiology
Jean WongFrances Chung

Abstract

Delirium is a common problem that occurs in 5-50% of elderly individuals following surgery. Patients who develop delirium after surgery are at increased risk for serious complications. Recent studies suggest that patients with obstructive sleep apnea (OSA), a sleep disorder characterized by repeated episodes of complete or partial blockage of the upper airway - are at greater risk to develop delirium. OSA is more common in elderly individuals but is often undiagnosed. Identification and treatment of unrecognized OSA may reduce the incidence of postoperative delirium. However, few studies have investigated the effect of perioperative treatment of OSA to prevent postoperative delirium. This multi-centre randomized controlled trial will enrol 634 elderly patients undergoing elective hip/knee replacement surgery. The study has been approved by the Research Ethics Boards of the three participating institutions. Patients will be screened with the STOP-Bang questionnaire. Those with a score of 3 or greater will have a portable home sleep study using the ApneaLink™ Air device. Patients identified to have OSA will be randomized to 1) Auto-titrating continuous positive airway pressure (APAP) applied during sleep for 72 h after surgery or...Continue Reading

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References

Dec 15, 1990·Annals of Internal Medicine·S K InouyeR I Horwitz
Apr 1, 1980·The American Journal of Psychiatry·W H Berrettini
Dec 13, 2000·International Journal of Geriatric Psychiatry·S BorsonA Dokmak
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·J M MontserratE Ballester
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·Curtis N SesslerR K Elswick
Feb 1, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R Sean MorrisonAlbert L Siu
Sep 27, 2003·Journal of the American Geriatrics Society·Soo BorsonMary Ganguli
Dec 23, 2003·Journal of the American Geriatrics Society·Jane McCuskerEric Belzile
Jul 30, 2004·American Journal of Respiratory and Critical Care Medicine·Juan F MasaJosé M Montserrat
Jun 18, 2005·International Journal of Geriatric Psychiatry·A M ContínF Ramos
Mar 17, 2006·The New England Journal of Medicine·Sharon K Inouye
Jan 16, 2008·Archives of Internal Medicine·Douglas L LeslieSharon K Inouye
Feb 6, 2008·Proceedings of the American Thoracic Society·Naresh M Punjabi
Apr 24, 2008·Anesthesiology·Frances ChungColin M Shapiro
Nov 3, 2010·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Adam BlackmanWillis Tsai
Mar 10, 2012·British Journal of Anaesthesia·F ChungY Sun
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla
Sep 3, 2013·American Journal of Respiratory and Critical Care Medicine·Richard J SchwabUNKNOWN ATS Subcommittee on CPAP Adherence Tracking Systems
Sep 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Jens RoggenbachStefan Hofer
Oct 8, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Emily YoungblomJacqueline Leung
Dec 17, 2014·Journal of the American Geriatrics Society·UNKNOWN American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults
Apr 22, 2017·Anesthesia and Analgesia·Enoch W K LamJean Wong

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Citations

Apr 1, 2020·Clinical Obstetrics and Gynecology·Tahmina Karimyar, Leonardo Pereira
Apr 17, 2020·Journal of Anesthesia·Barry N Swerdlow
Jul 20, 2021·The Cochrane Database of Systematic Reviews·Jennifer K BurtonTerry J Quinn
Nov 27, 2021·The Cochrane Database of Systematic Reviews·Jennifer K BurtonTerry J Quinn

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