The prevention of 'dry socket' with topical metronidazole in general dental practice

British Dental Journal
D ReekieH Devlin

Abstract

The purpose of the study was to determine if the intra-alveolar application of topical metronidazole gel could reduce the incidence of alveolar osteitis (dry socket) following routine tooth extraction in molar and premolar extraction sites. This was a multicentre, double blind, randomised, placebo-controlled clinical trial. A total of 302 patients took part, of which 23 returned with alveolar osteitis. Of these, eight had received the metronidazole gel and 15 the placebo. The study was carried out in three general dental practices by general dental practitioners working in England over the period 2000-2003. Following extraction of either a molar or premolar tooth, either a 25% metronidazole gel or KY Jelly was syringed gently into the socket. A painful post operative complication was recorded if either a dry socket was present or the patient returned with pain. The difference in the incidence of alveolar osteitis between the placebo and the active gel groups was not significant and it was concluded that 25% topical metronidazole gel was not effective in reducing the incidence of alveolar osteitis. It was found that the incidence of alveolar osteitis reduced with increasing age and was more likely to occur in a patient with a pr...Continue Reading

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Citations

Oct 23, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yan Qiu Li, Zeng Chun Shan
Mar 11, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ronaldo Célio MarianoAmanda de Carvalho Silva
Aug 9, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Eva RamosIcíar Arteagoitia
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Blánaid DalyHelen V Worthington
Sep 26, 2009·Analytical and Bioanalytical Chemistry·Cornelia WeberChristine Kranz
Oct 24, 2017·Journal of the Association for Information Science and Technology·David KauchakAlan Hogue
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Giovanni LodiSusan Furness
Aug 5, 2017·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Srinivas Chakravarthi
Jul 3, 2018·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mohammad Ali SaghiriNader Sheibani
May 8, 2018·Journal of the Korean Association of Oral and Maxillofacial Surgeons·John Mamoun
Feb 25, 2021·The Cochrane Database of Systematic Reviews·Giovanni LodiMaddalena Manfredi

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