The prevention of emergence agitation with tropisetron or clonidine after sevoflurane anesthesia in small children undergoing adenoidectomy

Anesthesia and Analgesia
Ulla LankinenP Tarkkila

Abstract

Postoperative agitation is a common problem after sevoflurane anesthesia in children. In the present study, we evaluated if tropisetron or clonidine could reduce the incidence of postoperative agitation after day case adenoidectomy in small children. We included 75 unpremedicated children aged 1-7 yr who were randomly assigned to receive either placebo, tropisetron (0.1 mg/kg) or clonidine (1.5 microg/kg) after anesthesia induction. Anesthesia was induced and maintained with sevoflurane. Patients also received alfentanil (20 microg/kg) and diclofenac (1 mg/kg). Postoperative pain was treated with IV oxycodone (0.05 mg/kg). Time to achieve discharge criteria was recorded. Modified pain/discomfort scale was used assess the postoperative behavior. The incidence of postoperative agitation was significantly less (32%, 8/25 patients) in the tropisetron group compared with placebo (62%, 16/26 patients), P < 0.05). Clonidine could not prevent agitation (incidence 54%, 13/24). No adverse effects were noted during the study. Discharge times were similar between the groups (between 80 and 99 min on average). In conclusion, tropisetron 0.1 mg/kg significantly reduced the incidence of postoperative agitation after sevoflurane anesthesia. Cl...Continue Reading

References

Feb 7, 1998·Anaesthesia and Intensive Care·S M WalkerA Richards
Mar 5, 1998·Anaesthesia·G Djaiani, S Ridley
Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ViitanenP Annila
May 26, 1999·Acta Anaesthesiologica Scandinavica·A Beskow, P Westrin
May 23, 2003·Anesthesia and Analgesia·Terri Voepel-LewisAlan R Tait
Dec 25, 2003·Anesthesia and Analgesia·Mauricio E IbacacheAnita L Morales

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Citations

Oct 1, 2010·International Journal of Pediatric Otorhinolaryngology·Alparslan ApanFiliz Datli Tahran
Feb 12, 2013·Journal of Pediatric Ophthalmology and Strabismus·Laura J HeinmillerAdam R Thode
Apr 24, 2012·Expert Opinion on Pharmacotherapy·Hannu KokkiSari Sjövall
May 23, 2007·Masui. The Japanese journal of anesthesiology·Norifumi Kuratani
Jan 29, 2014·The Cochrane Database of Systematic Reviews·Paul LambertPhilippa Middleton
Sep 13, 2014·The Cochrane Database of Systematic Reviews·David CostiPhilippa Middleton
Sep 9, 2006·Current Opinion in Anaesthesiology·Kristin Engelhard, Christian Werner
May 5, 2007·Current Opinion in Anaesthesiology·Jerrold Lerman
Jul 28, 2007·European Journal of Anaesthesiology·W FunkJ Geroldinger
Jul 3, 2015·The Cochrane Database of Systematic Reviews·Joseph F StandingMarina Waddington
May 3, 2019·Current Opinion in Anaesthesiology·Arash Afshari
Nov 1, 2016·Paediatric Drugs·Arthura D Moore, Doralina L Anghelescu

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