The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model

Surgery
Hizir AkyildizKemal Deniz

Abstract

Chemokines are proinflammatory proteins that participate in immune and inflammatory responses through chemoattraction and leukocyte activation. The chemokine antagonist Met-RANTES (Regulated upon Activation Normal T cell Expressed and Secreted) has been shown to be efficacious in decreasing inflammation in several animal disease models. The purpose of this study was to investigate the effects of administration of Met-RANTES on intra-abdominal adhesion formation after abdominal operation. A 42 and 4-month-old female Wistar-Albino rats were subjected to standardized lesions by cauterization of the cecum and uterine horn. They were divided randomly into 3 groups containing 14 rats each: group 1 (control), operative procedure without further treatment; group 2 (Seprafilm), operative procedure with an antiadhesive membrane; 2 x 1 cm of Seprafilm was interposed beneath the peritoneal incision, and group 3 (Met-RANTES), operative procedure with the chemokine antagonist Met-RANTES. The extent and severity of adhesions at the operative site were evaluated. Light microscopic examination was performed to determine semiquantitative scores of VEGF expression. Rats in the control group formed extensive adhesions. In comparison with the contr...Continue Reading

References

Jan 1, 1994·International Archives of Allergy and Immunology·Y KameyoshiS Yamamoto
Aug 1, 1995·The British Journal of Surgery·M Snoj
Apr 5, 1996·Science·E C Butcher, L J Picker
Feb 15, 1997·Lancet·D H Adams, A R Lloyd
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Apr 9, 1999·Anesthesia and Analgesia·B CelebiogluS Atakan
Feb 19, 2002·Kidney International·Erwei SongUwe Heemann
Dec 6, 2003·Circulation Research·Niels R VeillardFrançois Mach
Dec 3, 2004·ANZ Journal of Surgery·Bruce P Waxman
Dec 22, 2004·Archives of Surgery·Kaya SaribeyoğluKenan Ulualp
Jul 12, 2005·Human Reproduction·Murat BerkkanogluAydin Arici
Jan 10, 2006·American Journal of Surgery·Can KucukSebahattin Muhtaroglu
Mar 6, 2007·Gynécologie, obstétrique & fertilité·S Ait MenguelletD Vinatier

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Citations

Aug 10, 2011·Biochemical Pharmacology·Andy ChevignéSabrina Deroo
Jul 19, 2015·International Journal of Surgery·Hui ZhangYaoyao Bian
Jan 27, 2015·The Journal of Surgical Research·Ming-Hua DuSen Hu

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