The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

American Journal of Otolaryngology
Yeo-Hoon YoonYong Ho Park

Abstract

The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model. This is a randomized, controlled animal study. Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination. External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration. This study suggests that MMC can be helpful in preventing EAC fibrosis after injury.

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Citations

Apr 15, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·In Youb ChangSang Pil Yoon
Oct 16, 2015·Acta Cirúrgica Brasileira·Maria de Fátima Pereira de CarvalhoFernando de Andrade Quintanilha Ribeiro
Jan 16, 2014·Psychophysiology·Carles Escera, Manuel S Malmierca
Dec 18, 2013·Brain Topography·Flora M Antunes, Manuel S Malmierca
Apr 30, 2015·Brain Structure & Function·Fei Gao, Albert S Berrebi
Dec 24, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Eric R OliverBradley W Kesser
Jul 14, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dustin M LangCarolyn O Dirain
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Mona MozaffariAbigail S Tucker

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