PMID: 7335496Dec 21, 1981Paper

The primary and secondary structure of yeast 26S rRNA

Nucleic Acids Research
G M VeldmanJ P Ebel

Abstract

We present the sequence of the 26S rRNA of the yeast Saccharomyces carlsbergensis as inferred from the gene sequence. The molecule is 3393 nucleotides long and consists of 48% G+C; 30 of the 43 methyl groups can be located in the sequence. Starting from the recently proposed structure of E. coli 23S rRNA (see ref. 25) we constructed a secondary structure model for yeast 26S rRNA. This structure is composed of 7 domains closed by long-range base pairings as n the bacterial counterpart. Most domains show considerable conservation of the overall structure; unpaired regions show extended sequence homology and the base-paired regions contain many compensating base pair changes. The extra length of the yeast molecule is due to a number of insertions in most of the domains, particularly in domain II. Domain VI, which is extremely conserved, is probably part of the ribosomal A site. alpha-Sarcin, which apparently inhibits the EF-1 dependent binding of aminoacyl-tRNA, causes a cleavage between position 3025 and 3026 in a conserved loop structure, just outside domain VI. Nearly all of the located methyl groups, like in E. coli, are present in domain II, V and VI and clustered to a certain extent mainly in regions with a strongly conserve...Continue Reading

References

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Citations

Apr 1, 1990·Plant Molecular Biology·C J Meduski, J Velten
Apr 1, 1983·Current Genetics·E Bartnik, P Borsuk
Jan 1, 1987·Journal of Molecular Evolution·J L GorskiR D Schmickel
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Jan 1, 1986·Progress in Biophysics and Molecular Biology·K Nagano, M Harel
Aug 1, 1985·Molecular and Biochemical Parasitology·T R UnnaschD F Wirth
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Jan 1, 1986·Bio Systems·S A Gerbi
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T OtsukaY Sakaki
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G T OostergetelM Boublik
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R N Nazar, W W Wong
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I L GonzalezR D Schmickel
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·V F de la CruzL Simpson
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A BaroinA Adoutte
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L KretznerM Rosbash
Jan 1, 1982·DNA·H R ChenB C Orcutt
Aug 11, 1982·Nucleic Acids Research·H G Köchel, H Küntzel

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