Abstract
Autoaggression and autoimmune attack are established vernacular in the literature of autoimmune disease, and reflect the popular view that autoimmunity is a disease of immune dysregulation in which the immune system inappropriately attacks healthy tissues. The aim of this article is to focus attention on an alternative, indeed opposite, view--that autoimmunity represents the response to a primary lesion in the target tissue, rather than its cause, and that like alloimmunity, autoimmunity is physiological appropriate and protective. The cell death and tissue damage which results is characteristic of an immune response programmed to eliminate immunogen, remove detritus and isolate the lesion.
References
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K Sege, P A Peterson
Jan 4, 1987·Nature·K OgasawaraR H Schwartz
Jan 1, 1987·Annual Review of Immunology·A DavidsonB Diamond
Jan 1, 1989·Autoimmunity·T Wilkin
Jan 1, 1989·Autoimmunity·E Malatzky-Goshen, Y Shoenfeld
Oct 1, 1989·Diabetologia·K YamagataN Kono
Oct 1, 1989·Diabetologia·M ShibataA L Notkins
Dec 1, 1989·Immunology Today·I R Cohen
Oct 1, 1989·Diabetologia·E F LampeterP Pozzilli
Aug 1, 1989·Immunology Today·A Coutinho, A Bandeira
Jan 1, 1988·Autoimmunity·R Volpé
Jan 1, 1985·Endocrine Reviews·K D Burman, J R Baker
Jan 1, 1988·Autoimmunity·F HeidenreichJ Newsom-Davis
Oct 15, 1987·Nature·J A ToddH O McDevitt
Feb 1, 1988·Australian Veterinary Journal·A D ThomasK F Trueman
Feb 1, 1988·Journal of Endocrinological Investigation·B E WenzelP C Scriba
Jan 15, 1987·Nature·T E AdamsD Hanahan
Sep 2, 1985·Nature·B P BabbittE R Unanue
Mar 1, 1985·Molecular Immunology·D MaleI Roitt
Dec 25, 1971·Lancet·A C Allison
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·M BorgesS H Ingbar
Oct 8, 1983·Lancet·P H Plotz
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N H WassermannB F Erlanger
Jan 1, 1983·European Journal of Immunology·M N IslamN R Farid
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A MatisR H Schwartz
Jan 1, 1987·Immunology Today·R KoflerA N Theofilopoulos
Citations
Nov 24, 1995·Pharmacy World & Science : PWS·B A t Hart, H G Otten
Aug 11, 2011·Cell Biochemistry and Biophysics·Li ShaoHua Zhang
Aug 22, 2003·Thyroid : Official Journal of the American Thyroid Association·Su-Chin HoDaphne H Khoo
Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·R Volpé
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·E ResetkovaR Volpé
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·R Volpé
Apr 1, 1995·Thyroid : Official Journal of the American Thyroid Association·R M CuddihyR S Bahn
Jan 27, 1999·Thyroid : Official Journal of the American Thyroid Association·S ShoreyP G Walfish
Jun 12, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bert A 't Hart, Wilfred F den Dunnen
Sep 1, 2007·Expert Review of Clinical Immunology·Bert A 't HartHerbert Pm Brok
Jan 1, 1995·Autoimmunity·S HaralambousP Lymberi
Mar 27, 2001·Autoimmunity·B P Reines
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Apr 17, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Bert A 't Hart, Robert Weissert
Jun 28, 2001·Clinical and Diagnostic Laboratory Immunology·V KumarJ Wortsman
Jan 1, 1992·Autoimmunity·R Volpé
Feb 29, 2020·Primate Biology·Bert A 't Hart
Mar 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R Volpé
Jan 8, 2021·Annals of Neurology·Antonio LuchicchiJeroen J G Geurts
Dec 19, 2020·International Immunology·Toshio Hirano