The principal features and mechanisms of dopamine modulation in the prefrontal cortex

Progress in Neurobiology
J K Seamans, Charles R Yang

Abstract

Mesocortical [corrected] dopamine (DA) inputs to the prefrontal cortex (PFC) play a critical role in normal cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of working memory function, planning and attention, and its dysfunctions may underlie positive and negative symptoms and cognitive deficits associated with schizophrenia. Despite intense research, there is still a lack of clear understanding of the basic principles of actions of DA in the PFC. In recent years, there has been considerable efforts by many groups to understand the cellular mechanisms of DA modulation of PFC neurons. However, the results of these efforts often lead to contradictions and controversies. One principal feature of DA that is agreed by most researchers is that DA is a neuromodulator and is clearly not an excitatory or inhibitory neurotransmitter. The present article aims to identify certain principles of DA mechanisms by drawing on published, as well as unpublished data from PFC and other CNS sites to shed light on aspects of DA neuromodulation and address some of the existing controversies. Eighteen key features about DA modulation have been identified. These points directly impact on the end result of DA neuromodul...Continue Reading

References

May 26, 1978·Science·J D BarchasS J Watson
Feb 26, 1976·Experimental Brain Research·S T KitaiJ D Kocsis
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A PeredaD S Faber
Dec 9, 1991·Neuroscience Letters·I D HentallL Gollapudi
Feb 22, 1991·Science·T Sawaguchi, P S Goldman-Rakic
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D K GrandyO Civelli
Aug 1, 1990·The Journal of Physiology·J C Hirsch, F Crepel
May 1, 1990·Brain Research. Brain Research Reviews·R M Wightman, J B Zimmerman
Feb 1, 1986·Pflügers Archiv : European journal of physiology·C MarchettiH D Lux
Sep 1, 1989·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B A EllenbroekA R Cools
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-RakicM Geffard
Jan 9, 1989·Brain Research·S Bernath, M J Zigmond
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R D Oades
Nov 2, 1973·Science·A M ThierryJ Glowinski

❮ Previous
Next ❯

Citations

May 24, 2007·Molecular Neurobiology·Xiu-Ti Hu
Aug 3, 2005·Psychopharmacology·Mark R Wade, George G Nomikos
May 4, 2006·Psychopharmacology·Stan B Floresco, Orsolya Magyar
Nov 7, 2006·Psychopharmacology·Christopher C LapishJeremy K Seamans
Jan 13, 2010·Psychopharmacology·Laura M RowlandHenry H Holcomb
Jul 6, 2010·Psychopharmacology·Ava-Ann AllmanGillian A O'Driscoll
Mar 9, 2007·Experimental Brain Research·Barbara BliemHubert R Dinse
May 25, 2007·Experimental Brain Research·Viktor M Storozhuk, Larissa E Zinyuk
Mar 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·David ZillesOliver Gruber
Sep 2, 2011·Psychological Research·Onur Güntürkün
Aug 25, 2007·Brain Structure & Function·Walter B Hoover, Robert P Vertes
Jun 21, 2011·Journal of Neural Transmission·Yoanna Arlina KurnianingsihKang Sim
Dec 21, 2011·Journal of Neural Transmission·Martin SchecklmannMarcel Romanos
Sep 12, 2008·Journal of Computational Neuroscience·Klaus M StiefelTerrence J Sejnowski
Mar 7, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Benjamin B GelmanVicki M Soukup
Feb 13, 2010·Neurotoxicity Research·Patricio O'Donnell
Jun 15, 2013·Behavioural Brain Research·K A ButtsA G Phillips
Jul 16, 2013·Journal of Physiology, Paris·Hidehiko Takahashi
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Giuseppe Blasi, Alessandro Bertolino
Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Mar 24, 2011·Expert Reviews in Molecular Medicine·Charlotte TyePhilip Asherson
Jul 13, 2006·Journal of Personality and Social Psychology·Jan WackerGerhard Stemmler
Sep 6, 2012·Psychology and Aging·Nichole R LighthallMara Mather
Apr 12, 2005·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Brain Research. Brain Research Reviews
Patricia S Goldman-RakicGraham V Williams
Proceedings of the National Academy of Sciences of the United States of America
Venkata S MattayDaniel R Weinberger
© 2021 Meta ULC. All rights reserved