The principles of guiding by RNA: chimeric RNA-protein enzymes

Nature Reviews. Genetics
Alexander Hüttenhofer, Peter Schattner

Abstract

The non-protein-coding transcriptional output of the cell is far greater than previously thought. Although the functions, if any, of the vast majority of these RNA transcripts remain elusive, out of those for which functions have already been established, most act as RNA guides for protein enzymes. Common features of these RNAs provide clues about the evolutionary constraints that led to the development of RNA-guided proteins and the specific biological environments in which target specificity and diversity are most crucial to the cell.

References

Jan 1, 1988·Annual Review of Genetics·C Guthrie, B Patterson
Aug 1, 1995·Molecular Microbiology·L A Kirsebom
Nov 26, 1999·Gene·Z Dominski, W F Marzluff
Jul 13, 2000·Cell·K M Wassarman, G Storz
May 22, 2001·Molecular Microbiology·P P DennisT Lowe
Dec 6, 2001·Nature Reviews. Genetics·S R Eddy
Mar 21, 2002·FEBS Letters·James Ofengand
May 15, 2002·Cell·Jennifer A Doudna, Virginia L Rath
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thean-Hock TangAlexander Hüttenhofer
Jul 12, 2002·Nature·Jennifer A Doudna, Thomas R Cech
Aug 24, 2002·Science·Thomas A VolpeRobert A Martienssen
Aug 24, 2002·Science·Brenda J Reinhart, David P Bartel
Nov 15, 2002·The Journal of Biological Chemistry·Wayne A Decatur, Maurille J Fournier
Nov 30, 2002·Biochimie·Jean Pierre BachellerieAlexander Hüttenhofer
Nov 30, 2002·Current Opinion in Microbiology·Tamara L Horton, Laura F Landweber
Dec 10, 2002·Current Opinion in Chemical Biology·Alexander HüttenhoferJean Pierre Bachellerie
Jan 21, 2003·Genes & Development·Anita K Hopper, Eric M Phizicky
Aug 16, 2003·Developmental Cell·Alexei A AravinThomas Tuschl
Nov 19, 2003·Molecular Microbiology·Aixia ZhangSusan Gottesman
Nov 25, 2003·Nature Reviews. Genetics·Manyuan LongWen Wang
Jan 13, 2004·Nucleic Acids Research·Paul F Agris
Jan 24, 2004·The EMBO Journal·Thomas A Geissmann, Danièle Touati
Feb 28, 2004·Science·Simon W-L ChanSteven E Jacobsen
Jun 16, 2004·Current Opinion in Genetics & Development·Kazufumi Mochizuki, Martin A Gorovsky
Jul 31, 2004·Science·Jidong LiuGregory J Hannon
Aug 10, 2004·Nature Structural & Molecular Biology·Tiffany A AllenJennifer F Kugel
Sep 17, 2004·Nature·Gunter Meister, Thomas Tuschl
Jan 5, 2005·Nature Reviews. Genetics·Marjori A Matzke, James A Birchler
Feb 5, 2005·Trends in Biochemical Sciences·Kenneth D StuartAswini K Panigrahi
Feb 19, 2005·Current Opinion in Structural Biology·Mario Halic, Roland Beckmann
Mar 3, 2005·Genes & Development·Yukihide Tomari, Phillip D Zamore

❮ Previous
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Citations

Dec 16, 2006·Current Genetics·Andrea Hinas, Fredrik Söderbom
Jul 3, 2010·Molecular Genetics and Genomics : MGG·Keita MiyoshiHaruhiko Siomi
Oct 20, 2011·Plant Molecular Biology·Yingyin Yao, Qixin Sun
Oct 24, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Isaac Salazar-Ciudad
Feb 5, 2011·Nature Protocols·Mathieu Rederstorff, Alexander Hüttenhofer
Dec 7, 2007·Nature Structural & Molecular Biology·Bo LiangHong Li
Feb 13, 2010·Nucleic Acids Research·Mathieu RederstorffAlexander Hüttenhofer
Apr 12, 2012·Nucleic Acids Research·Konstantinia SkrekaAlexander Hüttenhofer
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·D MoazedS P Gygi
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·G J HannonJ A Steitz
Oct 27, 2010·RNA·Lucien BergeronSherif Abou Elela
Jan 30, 2008·PLoS Genetics·Hideya Kawaji, Yoshihide Hayashizaki
Aug 15, 2009·PLoS Pathogens·Roland HutzingerAlexander Hüttenhofer
Oct 3, 2014·Acta Biochimica Et Biophysica Sinica·Yongming XuDongping Du
Jan 13, 2015·Science China. Life Sciences·Yin ZhangLiangHu Qu
Mar 21, 2009·Journal of Molecular Biology·Constanze NandyNorbert Polacek
Feb 23, 2008·Seminars in Cancer Biology·Zeljka Pezer, Durdica Ugarković
Feb 18, 2011·Mass Spectrometry Reviews·Hiroshi NakayamaToshiaki Isobe
Feb 7, 2012·Journal of Biotechnology·Matthias HacklJohannes Grillari
Jun 29, 2016·Experimental Neurology·M LeindersL S Sorkin
Nov 3, 2006·Biopolymers·S Elizabeth McDowellNils G Walter
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·A Gregory MateraMichael P Terns
Jul 9, 2013·Essays in Biochemistry·Michael B ClarkJohn S Mattick
May 11, 2018·Biochemistry·Zachary J KartjeKeith T Gagnon
May 17, 2007·Genes & Development·Haruhiko Siomi, Mikiko C Siomi

❮ Previous
Next ❯

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