The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age

Scientific Reports
Ashley E WalkerLisa A Lesniewski

Abstract

Atherogenic remodeling often occurs at arterial locations with disturbed blood flow (i.e., low or oscillatory) and both aging and western diet (WD) increase the likelihood for pro-atherogenic remodeling. However, it is unknown if old age and/or a WD modify the pro-atherogenic response to disturbed blood flow. We induced disturbed blood flow by partial carotid ligation (PCL) of the left carotid artery in young and old, normal chow (NC) or WD fed male B6D2F1 mice. Three weeks post-PCL, ligated carotid arteries had greater intima media thickness, neointima formation, and macrophage content compared with un-ligated arteries. WD led to greater remodeling and macrophage content in the ligated artery compared with NC mice, but these outcomes were similar between young and old mice. In contrast, nitrotyrosine content, a marker of oxidative stress, did not differ between WD and NC fed mice, but was greater in old compared with young mice in both ligated and un-ligated carotid arteries. In primary vascular smooth muscle cells, aging reduced proliferation, whereas conditioned media from fatty acid treated endothelial cells increased proliferation. Taken together, these findings suggest that the remodeling and pro-inflammatory response to ...Continue Reading

References

Dec 1, 1987·Atherosclerosis·B PaigenR A Williams
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M B StemermanR Gardner
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R L ReddickN Maeda
Jan 14, 1999·The New England Journal of Medicine·R Ross
Nov 2, 2002·Nature Medicine·Victor J DzauDaniel G Sedding
Oct 25, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Vyacheslav A Korshunov, Bradford C Berk
Nov 8, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Paul A VanderLaanGodfrey S Getz
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Daniele TorellaMassimo Chiariello
Feb 13, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lisa A LesniewskiDouglas R Seals
Mar 24, 2009·Annual Review of Immunology·Elena Galkina, Klaus Ley
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Douglas NamHanjoong Jo
Oct 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Sheik J KhanRoberto I Vazquez-Padron
Apr 17, 2010·Atherosclerosis·Colin N YoungPaul J Fadel
Jan 20, 2011·Clinical Science·Douglas R SealsAnthony J Donato
Apr 23, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Li LiDavid G Harrison
May 31, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A LesniewskiDouglas R Seals
Feb 5, 2014·JAMA Internal Medicine·Quanhe YangFrank B Hu
Apr 25, 2014·Physiological Reports·Grant D HensonLisa A Lesniewski
May 18, 2017·Lab on a Chip·Xudong ZhangIoana Voiculescu
Nov 28, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P M Clifton, J B Keogh
Jun 16, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Yapei LiAlex F Chen

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Methods Mentioned

BETA
dissection
light microscopy

Software Mentioned

ImageJ
Vascular Research Tools
SPSS

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