The probabilistic aggregate consumer exposure model (PACEM): validation and comparison to a lower-tier assessment for the cyclic siloxane D5

Environment International
Tatsiana DudzinaNatalie Von Goetz

Abstract

Current practice of chemical risk assessment for consumer product ingredients still rarely exercises the aggregation of multi-source exposure. However, focusing on a single dominant source/pathway combination may lead to a significant underestimation of the risk for substances present in numerous consumer products, which often are used simultaneously. Moreover, in most cases complex multi-route exposure scenarios also need to be accounted for. This paper introduces and evaluates the performance of the Probabilistic Aggregate Consumer Exposure Model (PACEM) applied in the context of a tiered approach to exposure assessment for ingredients in cosmetics and personal care products (C&PCPs) using decamethylcyclopentasiloxane (D5) as a worked example. It is demonstrated that PACEM predicts a more realistic, but still conservative aggregate exposure within the Dutch adult population when compared to a deterministic point estimate obtained in a lower tier screening assessment. An overall validation of PACEM is performed by quantitatively relating and comparing its estimates to currently available human biomonitoring and environmental sampling data. Moderate (by maximum one order of magnitude) overestimation of exposure is observed due ...Continue Reading

References

Jul 1, 1997·Toxicology and Industrial Health·R P BrownR P Beliles
Nov 22, 2002·Risk Analysis : an Official Publication of the Society for Risk Analysis·Deborah H BennettOlivier Jolliet
Dec 21, 2002·Chemosphere·John S EvansKirk R Smith
Jan 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sudarsanan VaraprathKathleen P Plotzke
Jul 17, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Micaela B ReddyMelvin E Andersen
Jan 8, 2008·Regulatory Toxicology and Pharmacology : RTP·Marina L JovanovicKathleen P Plotzke
Apr 30, 2008·Archives of Environmental Contamination and Toxicology·Yuichi Horii, Kurunthachalam Kannan
Jun 28, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Micaela B ReddyMelvin E Andersen
Jun 24, 2010·Environmental Science & Technology·Michael S McLachlanCarsten A Skjøth
Sep 3, 2010·Archives of Environmental Contamination and Toxicology·Yan LuKurunthachalam Kannan
Feb 26, 2011·Environmental Science & Technology·David TrudelKonrad Hungerbühler
May 26, 2011·Journal of Exposure Science & Environmental Epidemiology·Torkjel M SandangerEiliv Lund
Sep 6, 2011·Environmental Science & Technology·Xiangmei May WuDeborah H Bennett
Jan 25, 2012·International Journal of Toxicology·Wilbur JohnsonF Alan Andersen
Nov 24, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jacqueline W H BiesterbosNel Roeleveld
Feb 21, 2013·Environmental Science & Technology·Andreas M BuserKonrad Hungerbühler
Jun 27, 2013·Journal of Exposure Science & Environmental Epidemiology·Ilse GosensA Gerlienke Schuur
Oct 30, 2014·Journal of Exposure Science & Environmental Epidemiology·Christiaan DelmaarGerlienke Schuur
Dec 3, 2014·Environment International·Jacqueline W H BiesterbosPaul T J Scheepers

❮ Previous
Next ❯

Citations

Jul 25, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seul Min Choi, Byung-Mu Lee
Apr 9, 2016·Environment International·Daniela CapelaLúcia Santos
Apr 12, 2016·Environment International·Alexi S ErnstoffOlivier Jolliet
Jun 21, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sarah A TozerJ F Nash
Jun 20, 2016·Environment International·Peter FantkeOlivier Jolliet
Aug 10, 2016·Environmental Science & Technology·Natalie von Goetz
Feb 22, 2018·Environmental Science. Processes & Impacts·Yu-Mei TanPeter Egeghy
May 24, 2018·Journal of Exposure Science & Environmental Epidemiology·Klaus SchneiderJan Oltmanns
Dec 4, 2019·Journal of Exposure Science & Environmental Epidemiology·Peter FantkeYuri Bruinen de Bruin
Dec 7, 2018·Journal of Exposure Science & Environmental Epidemiology·Lesa AylwardSean M Hays
Dec 18, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Rogelio Tornero-VelezTimothy J Buckley
Apr 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mouhamadou M SyMatthias Greiner
Apr 10, 2021·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Kyu-Bong KimByung-Mu Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Regulatory Toxicology and Pharmacology : RTP
Christina E Cowan-Ellsberry, Steven H Robison
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
G ChevillotteA C Roudot
© 2021 Meta ULC. All rights reserved