The probabilities of one- and multi-track events for modeling radiation-induced cell kill

Radiation and Environmental Biophysics
Uwe SchneiderJürgen Besserer

Abstract

In view of the clinical importance of hypofractionated radiotherapy, track models which are based on multi-hit events are currently reinvestigated. These models are often criticized, because it is believed that the probability of multi-track hits is negligible. In this work, the probabilities for one- and multi-track events are determined for different biological targets. The obtained probabilities can be used with nano-dosimetric cluster size distributions to obtain the parameters of track models. We quantitatively determined the probabilities for one- and multi-track events for 100, 500 and 1000 keV electrons, respectively. It is assumed that the single tracks are statistically independent and follow a Poisson distribution. Three different biological targets were investigated: (1) a DNA strand (2 nm scale); (2) two adjacent chromatin fibers (60 nm); and (3) fiber loops (300 nm). It was shown that the probabilities for one- and multi-track events are increasing with energy, size of the sensitive target structure, and dose. For a 2 × 2 × 2 nm(3) target, one-track events are around 10,000 times more frequent than multi-track events. If the size of the sensitive structure is increased to 100-300 nm, the probabilities for one- and...Continue Reading

References

Nov 1, 1989·International Journal of Radiation Biology·D T Goodhead
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May 26, 2006·Physics in Medicine and Biology·L M GarciaG P Raaphorst
Aug 10, 2011·International Journal of Radiation Biology·Thomas FriedrichMichael Scholz
Nov 30, 2014·Zeitschrift für medizinische Physik·Jürgen Besserer, Uwe Schneider
Jan 27, 2015·Radiation and Environmental Biophysics·Jürgen Besserer, Uwe Schneider
May 2, 2017·Zeitschrift für medizinische Physik·Thomas Schalch

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Citations

Oct 17, 2017·International Journal of Radiation Biology·Bruce F Kimler
Apr 12, 2020·Radiation and Environmental Biophysics·Uwe SchneiderJürgen Besserer
Aug 25, 2021·Radiation and Environmental Biophysics·Sonwabile Arthur Ngcezu, Hans Rabus

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