The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade

Molecular Nutrition & Food Research
Iñaki Robles-VeraJuan Duarte

Abstract

Whether the probiotic Lactobacillus fermentum CECT5716 (LC40) ameliorates hypertension in rats with chronic nitric oxide (NO) synthase inhibition is tested. Rats are randomly divided into four different groups and treated for 4 weeks: a) vehicle (control), b) vehicle plus NG -nitro-l-arginine methyl ester (l-NAME; 50 mg 100 mL-1 in drinking water), c) LC40 (109 colony-forming units d-1 by gavage), and d) LC40 plus l-NAME. l-NAME induces gut dysbiosis, characterized mainly by an increased Fimicutes/Bacteroidetes (F/B) ratio and reduced Bifidobacterium content, increased Th17 cells and reduced Treg in mesenteric lymph nodes (MLN), increased aortic Th17 infiltration and reactive oxygen species, reduced aortic endothelium-dependent relaxant response to acetylcholine, and hypertension. LC40 prevents gut dysbiosis, alters the Th17/Treg balance in MLN, vascular oxidative stress, and inflammation, slightly improves endothelial dysfuncion but do not inhibit the development of l-NAME-induced hypertension. Chronic LC40 treatment, in this model of chronic inhibition of NO synthesis, reduces early events involved in atherosclerosis development, such as vascular oxidative stress and pro-inflammatory status, as a result of prevention of gut d...Continue Reading

References

Aug 15, 1996·The Journal of Clinical Investigation·M R TschudiT F Lüscher
Dec 18, 1998·Hypertension·R Zatz, C Baylis
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Jan 18, 2005·Science·Jan Hendrik NiessHans-Christian Reinecker
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Aug 2, 2007·Menopause : the Journal of the North American Menopause Society·Rocio VeraJuan Duarte
Dec 17, 2008·Mucosal Immunology·J R Mora, U H von Andrian
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·J Gregory CaporasoRob Knight
Jun 29, 2010·European Journal of Immunology·Akihiro Kimura, Tadamitsu Kishimoto
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Nov 3, 2011·The Journal of Clinical Investigation·Oscar Medina-ContrerasTimothy L Denning
Jun 22, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pushpinder DhillionBabbette LaMarca
Dec 25, 2012·Cardiovascular Research·Hoanglan NguyenBrett M Mitchell
Dec 24, 2013·Blood Pressure·Giuseppe ManciaFaiez Zannad
Aug 21, 2014·Journal of Dental Research·C J BacklundM H Schoenfisch
Sep 23, 2014·The Journal of Clinical Investigation·Annet KiraboDavid G Harrison
Oct 12, 2014·Free Radical Biology & Medicine·Embriette R HydeNathan S Bryan
Apr 15, 2015·Hypertension·Tao YangMansour Mohamadzadeh
Jul 4, 2015·Bioinformatics·Robert C Edgar, Henrik Flyvbjerg
Aug 11, 2015·Molecular Nutrition & Food Research·Manuel Gómez-GuzmánJuan Duarte
Aug 22, 2015·Circulation Research·Kandarp H ShahXiao Z Shen
Sep 1, 2015·Journal of the American Society of Nephrology : JASN·Ulrich WenzelHeimo Ehmke
Apr 30, 2016·Science·Thomas GensollenRichard S Blumberg
Jan 15, 2017·Molecular Nutrition & Food Research·Melissa N ConleyNorman G Hord
Mar 21, 2017·Current Hypertension Reports·Iñaki Robles-VeraJuan Duarte
Oct 1, 2015·Food Research International·Pablo C B LolloAdriano G Cruz
Sep 26, 2017·The Journal of Clinical Investigation·Natacha ColliouMansour Mohamadzadeh

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Citations

Dec 24, 2019·Clinical and Experimental Pharmacology & Physiology·Eman S H Abd AllahMona A Abd El-Rahman
Jun 8, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marta ToralRosario Jiménez
Jan 25, 2020·Chinese Medical Journal·Yao LiuWen-Zhi Hu
Jul 3, 2020·American Journal of Hypertension·Iñaki Robles-VeraJuan Duarte
Aug 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Iñaki Robles-VeraJuan Duarte
Feb 6, 2020·Journal of Dairy Science·Ignasi Azagra-BoronatM José Rodríguez-Lagunas
Jul 28, 2020·Frontiers in Cellular and Infection Microbiology·Zhongyi ZhaoChuanmin Tao
May 7, 2020·Frontiers in Physiology·Iñaki Robles-VeraJuan Duarte
Jan 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Iñaki Robles-VeraJuan Duarte
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xin ZhaoQilong Wang
Feb 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jose Alberto Molina-TijerasJulio Gálvez
Feb 10, 2021·International Journal of Environmental Research and Public Health·Joonatan PalmuTeemu Niiranen
Feb 18, 2021·Cellular and Molecular Neurobiology·Christopher L SoudersChristopher J Martyniuk
Apr 4, 2021·Nutrients·María Jesús Rodríguez-SojoAlba Rodríguez-Nogales
Jul 5, 2021·Bioorganic & Medicinal Chemistry·Fabio AriasM Encarnación Camacho

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