PMID: 11309766Apr 20, 2001Paper

The problem of cutoff levels in a screened population: appropriateness of informing screenees about their risk of having prostate carcinoma

Cancer
W HorningerA W Partin

Abstract

Transrectal prostate biopsy decisions often have been based on absolute cutoff values for total and free prostate-specific antigen (PSA). The authors decided that it would be more appropriate to develop risk profiles for the individual patient to allow him to decide whether to undergo a prostate biopsy. To develop risk profiles, the authors first used multivariate logistic regression analysis to analyze 2054 males who were part of the Tyrol (Austria) PSA Screening Project. Second, artificial neural network (ANN) analyses were performed using data from 3474 males who also were part of the Tyrol PSA Screening Project and who had undergone prostate biopsy. These analyses were compared with standard cutoff levels of specificity for the detection of prostate carcinoma. To the authors' knowledge, this was the first time that multivariate logistic regression analysis was used to decide whether to perform prostate biopsies based on risk profiles rather than on single cutoff levels. For the detection of prostate carcinoma, at sensitivity levels of 90--95%, the ANN was 150--200% more specific than the standard cutoff points. For screened volunteers with total PSA levels below 4 ng/mL, ANN showed a lower cancer predictive ability in compa...Continue Reading

References

Apr 25, 1991·The New England Journal of Medicine·W J CatalonaG L Andriole
Feb 1, 1991·Journal of Medical Systems·P S MaclinJ Rand
Jan 1, 1993·CA: a Cancer Journal for Clinicians·C C BoringT Tong
May 15, 1999·European Urology·W HorningerG Bartsch

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Citations

Aug 18, 2005·BJU International·Carsten StephanEleftherios P Diamandis
Apr 3, 2008·Current Opinion in Urology·Shahrokh F ShariatMichael W Kattan
Oct 1, 2008·Cancer·Shahrokh F ShariatMichael W Kattan
Jun 23, 2009·Cancer·Michael P HermanAshutosh Tewari
Sep 12, 2015·Future Oncology·Carsten StephanBernhard Ralla
Sep 25, 2004·The Prostate·Ralf HerwigGeorg Bartsch
Dec 17, 2009·Future Oncology·Shahrokh F ShariatPeter T Scardino
Feb 13, 2013·Nature Reviews. Urology·Xinhai HuCarsten Stephan

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