PMID: 6967952Jul 1, 1980Paper

The process dynamics of viral and bacterial diseases of the central nervous system

Journal of the Neurological Sciences
K FelgenhauerG Schliep

Abstract

Several patients with herpes simplex encephalitis developed a prolonged humoral immune reaction within the central nervous system, which was evaluated by the measurement of locally synthesized immunoglobulin fractions in cerebrospinal fluid. Such phasic immune responses seem to occur predominantly in CNS infections with herpes and myxo/paramyxo viruses. In many cases the B-cell response follows a primary neutrophilic and a secondary mononuclear phase. Most benign viral encephalomeningitis cases lack this type of strong local B-cell activity. This is also true in most cases of bacterial meningitis, that recover after a strong neutrophilic attack and a minor mononuclear reaction. The initial phase of a purulent meningitis is characterized by a complete breakdown of the blood-CSF barrier. This occurs also in some cases of "apurulent bacterial meningitis", that are characterized by very low CSF-cell counts in spite of a totally broken barrier. The "compartmental leucopenia" is interpreted as an imbalance between the supply from the blood and an intense phagocytic consumption within the CSF space. The influence of the hydrodynamic size of viruses on the mode of entry into the central nervous system and on the dynamics of the inflamm...Continue Reading

References

Jan 15, 1977·Lancet·K GrumbachT Klassen
May 18, 1978·Journal of Neurology·G Schliep, K Felgenhauer
Nov 1, 1978·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·G Schliep, K Felgenhauer
Nov 1, 1977·Annals of Neurology·K P Johnson, B J Nelson
Nov 1, 1978·Neurosurgery·E A Neuwelt, W K Clark
Jan 3, 1977·JAMA : the Journal of the American Medical Association·M M Thaler
Oct 1, 1976·Archives of Neurology·J S WolinskyC H Maitalnd
Apr 29, 1976·The New England Journal of Medicine·A Lowenthal, D Karcher
Aug 1, 1974·Journal of Medical Microbiology·J B Kurtz
Sep 1, 1973·The Journal of Experimental Medicine·F B KnottsJ G Stevens
May 1, 1974·Infection and Immunity·M L CookJ G Stevens
Aug 1, 1974·Journal of Medical Microbiology·F O MacCallumJ V Gostling
Dec 15, 1974·Klinische Wochenschrift·K Felgenhauer
May 1, 1974·Zeitschrift für ärztliche Fortbildung·G Pollex
Oct 1, 1972·Zeitschrift für Haut- und Geschlechtskrankheiten·J Angyal
Jan 1, 1968·Journal of Neuropathology and Experimental Neurology·R T Johnson
Jan 15, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Felgenhauer, D Hagedorn
Apr 1, 1954·The Journal of Experimental Medicine·D M HORSTMANNA D MASCOLA
Apr 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·H H KREUTZER, W H FENNIS
Apr 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·L M WEINER, B ZAK

❮ Previous
Next ❯

Citations

Jan 1, 1985·Journal of Neurology·K Felgenhauer, D Kober
Jan 19, 1984·The New England Journal of Medicine·R T JohnsonA Vaisberg
Dec 1, 1988·Journal of Neuroimmunology·P Berlit
Jan 1, 1988·Scandinavian Journal of Infectious Diseases·N A Peterslund

❮ Previous
Next ❯

Related Concepts

Related Feeds

Central Nervous System Bacterial Infections

Central nervous system bacterial infections are medical emergencies and include bacterial meningitis and spinal epidural abscess. Treatment with antibiotics can reduce morbidity and mortality. Discover the latest research on central nervous system bacterial infections here.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

© 2021 Meta ULC. All rights reserved