PMID: 15348008Sep 7, 2004Paper

The processing and characterization of animal-derived bone to yield materials with biomedical applications: part 1: modifiable porous implants from bovine condyle cancellous bone and characterization of bone materials as a function of processing

Journal of Materials Science. Materials in Medicine
G S JohnsonM A Lorier

Abstract

A study on the development of a process to form materials suitable for biomedical xenograft implants from bovine cancellous bone is presented. Bone cubes cut from the condyle portion of bovine femurs sourced from abattoir waste were subjected to a defatting and subsequent deproteination procedure to produce shape-modifiable materials in which the biocompatible mineral calcium hydroxycarbonate apatite component was preserved in the original osseous architecture of the bovine bone. Optimum defatting was achieved by (1) thawing of the precut bone cubes in water, (2) pressure cooking at 15 psi in water, (3) soaking in 0.1 mol l(-1) NaOH followed by a thorough rinse under running water, (4) microwave heating of the bone cubes in water, (5) refluxing in methyl acetate and finally (6) removal of internal liquid from the cubes by shaking and then air drying. Subsequent deproteination of the defatted bone cubes was optimally achieved by (1) soaking in 5% sodium hypochlorite solution at ambient temperature using ultrasonication, (2) thorough rinsing of the cubes in water followed by drying. The final product is a defatted/deproteinated, bleached material that can be molded into various shapes for implant use in the body. The bone specime...Continue Reading

Citations

Oct 19, 2007·Annals of Biomedical Engineering·Dong Seok Seo, Jong Kook Lee
Aug 19, 2007·International Endodontic Journal·M MarendingM Zehnder
May 29, 2012·Veterinary Surgery : VS·Richard G Kuipers von LandeAngela Hartman
May 10, 2005·Clinical Oral Implants Research·Andrew WorthHilary Burbidge
Jul 9, 2005·Journal of Biomaterials Science. Polymer Edition·Haiyan LiJiang Chang
Mar 23, 2011·Journal of Materials Science. Materials in Medicine·Thais Accorsi-MendonçaJosé Mauro Granjeiro
Apr 15, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·I O SmithE D Case
Mar 13, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jithendra T B RatnayakeGeorge J Dias

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