The procoagulant activity of red blood cells from patients with severe preeclampsia

American Journal of Obstetrics and Gynecology
D GrisaruA Eldor

Abstract

Our purpose was to determine whether red blood cells from patients with severe preeclampsia may exhibit increased membrane exposure of procoagulant phospholipids (i.e., phosphatidylserine), which may initiate intravascular clotting and platelet activation. The study group comprised 28 women: 9 with severe preeclampsia in the third trimester of pregnancy, 10 normotensive with uncomplicated pregnancies, and 9 age-matched, nonpregnant, healthy women. The exposure of phosphatidylserine on the outer membrane phospholipid layer was analyzed with use of isolated, washed red blood cells that were added as a source of phospholipids to a "prothrombinase" coagulation complex. The resultant thrombin formed was measured by an amidolytic assay. Thrombin generation significantly increased on the addition of red blood cells from women with preeclampsia (741 +/- 132 mU/ml/min) compared with red blood cells from normotensive pregnant (422 +/- 228 mU/ml/min) and nonpregnant women (316 +/- 268 mU/ml/min, p = 0.0008). This study indicates that in patients with preeclampsia the red blood cells exhibit a significant procoagulant surface that may trigger thrombin formation, thereby playing a role in the hypercoagulable state.

References

Feb 1, 1979·British Journal of Haematology·D ChiuS B Shohet
Sep 9, 1976·The New England Journal of Medicine·F Arias, R Mancilla-Jimenez
Apr 15, 1976·American Journal of Obstetrics and Gynecology·J A PritchardR A Mason
Jun 1, 1992·British Journal of Obstetrics and Gynaecology·M M AnceschiG C Di Renzo
Jun 1, 1992·Clinical Obstetrics and Gynecology·G G Zeeman, G A Dekker
Jun 11, 1992·Clinical Obstetrics and Gynecology·K G Perry, J N Martin
Nov 13, 1991·Biochimica Et Biophysica Acta·A J Schroit, R F Zwaal
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Sep 1, 1986·Thrombosis Research·F PekonenO Ylikorkala
Jan 1, 1986·The American Journal of Medicine·N D VaziriA Barbari
Jun 1, 1972·Obstetrical & Gynecological Survey·D G McKay
Jun 1, 1981·The Journal of Clinical Investigation·B LubinL L Van Deenen
Jan 1, 1994·Gynecologic and Obstetric Investigation·L HeilmannG F von Tempelhoff

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Citations

May 19, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·A-S Ducloy-Bouthors
Jun 28, 2000·The Journal of Obstetrics and Gynaecology Research·T SagesakaM Kaibara
Feb 13, 1999·American Journal of Obstetrics and Gynecology·M KaibaraK Aisaka
Dec 19, 2009·Cell Biochemistry and Biophysics·Alexander KoshkaryevSaul Yedgar
Aug 19, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezTinnakorn Chaiworapongsa
Mar 25, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Luca SpieziaPaolo Simioni
Dec 3, 2004·Annals of Saudi Medicine·I Cüneyt EvrükeOktay Kadayifçi
Apr 27, 2001·Anesthesia and Analgesia·M J HarnettK Bhavani-Shankar

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