The product of fasting plasma glucose and triglycerides improves risk prediction of type 2 diabetes in middle-aged Koreans

BMC Endocrine Disorders
Joung-Won LeeHyun-Young Park

Abstract

Screening for risk of type 2 diabetes mellitus (T2DM) is an important public health issue. Previous studies report that fasting plasma glucose (FPG) and triglyceride (TG)-related indices, such as lipid accumulation product (LAP) and the product of fasting glucose and triglyceride (TyG index), are associated with incident T2DM. We aimed to evaluate whether FPG or TG-related indices can improve the predictive ability of a diabetes risk model for middle-aged Koreans. 7708 Koreans aged 40-69 years without diabetes at baseline were eligible from the Korean Genome and Epidemiology Study. The overall cumulative incidence of T2DM was 21.1% (766 cases) in men and 19.6% (797 cases) in women. Therefore, the overall cumulative incidence of T2DM was 20.3% (1563 cases). Multiple logistic regression analysis was conducted to compare the odds ratios (ORs) for incident T2DM for each index. The area under the receiver operating characteristic curve (AROC), continuous net reclassification improvement (cNRI), and integrated discrimination improvement (IDI) were calculated when each measure was added to the basic risk model for diabetes. All the TG-related indices and FPG were more strongly associated with incident T2DM than WC in our study populat...Continue Reading

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Citations

Feb 23, 2020·Biology Open·Ellen Mayara Souza CruzFábio Rodrigues Ferreira Seiva
May 18, 2020·European Journal of Pediatrics·Luis E Simental-Mendía, Fernando Guerrero-Romero
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Xiuping XuanXuemei Xie

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