The product of the SHR3 orthologue of Aspergillus nidulans has restricted range of amino acid transporter targets

Fungal Genetics and Biology : FG & B
Zoi ErpapazoglouV Sophianopoulou

Abstract

The shrA gene of Aspergillus nidulans codes for a structural and functional homologue of Shr3p, a yeast ER membrane protein, which plays a crucial role in the secretory pathway of yeast amino acid permeases. shrA is a single-copy gene, whose expression is early activated during germination of A. nidulans conidiospores. ShrA is localized in the ER of the fungal cells and partially complements the shr3delta phenotype. Differently from Saccharomyces cerevisiae, where SHr3p is necessary for membrane localization of the majority of amino acid permeases, deletion of the shrA locus in A. nidulans impairs a limited number of amino acid uptake activities, including those responsible for proline and aspartate transport. Strongly reduced membrane levels of a PrnB-sGFP fusion in a shrAdelta background clearly suggest a direct role of ShrA in the topogenesis of the proline specific transporter.

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Citations

Aug 10, 2010·Eukaryotic Cell·Ioannis VangelatosVicky Sophianopoulou
Dec 23, 2009·Fungal Genetics and Biology : FG & B·Katerina RoumeliotiVicky Sophianopoulou
Apr 15, 2008·Fungal Genetics and Biology : FG & B·Demetra BouzarelouVicky Sophianopoulou
Nov 28, 2006·Fungal Genetics and Biology : FG & B·Areti PantazopoulouGeorge Diallinas
Oct 16, 2015·Scientific Reports·Alexandros AthanasopoulosVicky Sophianopoulou
Feb 9, 2006·Journal of Molecular Biology·Anna VlantiGeorge Diallinas
Oct 5, 2019·The FEBS Journal·George Diallinas, Olga Martzoukou
Oct 18, 2019·Microbiology and Molecular Biology Reviews : MMBR·Frans BianchiBert Poolman
Aug 6, 2020·International Journal of Molecular Sciences·Sofia Dimou, George Diallinas

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