PMID: 8457430Jan 1, 1993Paper

The production, buffering and efflux of protons in human skeletal muscle during exercise and recovery

NMR in Biomedicine
G J KempG K Radda

Abstract

We show how quantitative information about proton handling in human skeletal muscle in exercise and recovery can be obtained by 31P MRS and illustrate this with data from metabolic disorders. Proton production, proton efflux and passive buffering can be distinguished by comparing changes in [phosphocreatine] and pH at the end of exercise and by calculating ATP turnover during ischaemic exercise and in the 'natural experiment' of myophosphorylase deficiency (McArdle's disease). We calculate the effective buffer capacity to be 20-30 mmol/L/pH unit (slykes), somewhat lower than published measurements made in vitro but similar to other values obtained in vivo. This analysis is applied to data from normal muscle and a variety of disease states to estimate proton efflux during recovery and ATP production during exercise: (i) proton efflux during recovery is pH-dependent, reaching a 10 mmol/L/min at pH 6.2, and is increased in some cases of mitochondrial myopathy and in hypertension; (ii) glycogenolytic ATP production during exercise can reach 25 mmol/L/min in normal muscle and correlates approximately with [Pi] at the start of aerobic exercise and throughout ischaemic exercise; (iii) oxidative ATP production can reach 20-25 mmol/L/mi...Continue Reading

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Citations

Sep 26, 2000·Muscle & Nerve·D DurozardG Baverel
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C Hsu, M J Dawson
Feb 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J KempG K Radda
Mar 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J KempG K Radda
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J KempG K Radda
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D ShenM J Dawson
Dec 11, 2008·European Journal of Applied Physiology·Graham J KempRaffaele Lodi
Mar 4, 2009·European Journal of Applied Physiology·Gwenael LayecDavid Bendahan
Jun 1, 1993·Journal of the Neurological Sciences·G J KempG K Radda
Apr 1, 1993·Journal of the American College of Cardiology·S AdamopoulosG K Radda
Aug 31, 2001·Biophysical Chemistry·B Korzeniewski, J A Zoladz
Jan 22, 2002·Neuromuscular Disorders : NMD·M A ColeP Styles
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Jun 27, 2007·The Journal of General Physiology·Arie F Struyk, Stephen C Cannon
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Sep 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gwenael LayecDavid Bendahan
Sep 18, 2014·Scandinavian Journal of Medicine & Science in Sports·N DecorteB Wuyam
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May 13, 1998·Acta Physiologica Scandinavica·C Juel
Mar 28, 2006·The Tohoku Journal of Experimental Medicine·Naoto KimuraToshihito Katsumura

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