PMID: 2117639Sep 1, 1990Paper

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface

The Journal of Experimental Medicine
T Tsubata, Michael Reth

Abstract

We constructed expression vectors coding for the two pre-B-specific genes, VpreB and lambda 5, and transfected them together with a mu vector (mu tm) into Ig- myeloma cells. In a transfectant expressing all three introduced genes, the mu tm chain is transported on the cell surface. A biochemical analysis demonstrated that, in these cells, the mu tm chain is associated noncovalently with an 18-kD protein and covalently with a 22-kD protein, which are most likely the products of VpreB and lambda 5, respectively. Our results, thus, strongly suggest that the products of lambda 5 and VpreB bind to mu chains and have the same capacity as conventional Ig L chains to allow surface expression of mu chains.

Citations

Jan 1, 1992·International Journal of Cell Cloning·K Dorshkind, K S Landreth
Feb 6, 2002·Springer Seminars in Immunopathology·E M Fuentes-Pananá, J G Monroe
Feb 1, 1993·Immunology Today·F MelchersA Rolink
Dec 1, 1993·Immunology Today·M Groettrup, H von Boehmer
Apr 1, 1991·Current Opinion in Immunology·T Tsubata, S Nishikawa
Mar 2, 2005·Seminars in Immunology·Pierangela Sabbattini, Niall Dillon
Mar 1, 1997·Molecular Immunology·N KoenigJ Schwaber
Feb 5, 2000·Experimental Hematology·T TaguchiJ Fujimoto
Apr 1, 1997·Immunology and Cell Biology·H KarasuyamaK Kuida
Oct 7, 2009·Immunology and Cell Biology·Mark N Cruickshank, Daniela Ulgiati
Jul 5, 2006·Nature Immunology·Hui HuAnjana Rao
Jul 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Li XuRichard A Lerner
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N NishimotoM D Cooper
Jan 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·K IshiharaP W Kincade
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y AokiS Pillai
Nov 1, 1996·The Journal of Experimental Medicine·H JacobsA Berns
Dec 1, 1996·The Journal of Experimental Medicine·S GongM C Nussenzweig
Aug 26, 1998·The Journal of Experimental Medicine·E MeffreM C Nussenzweig
Feb 22, 2001·The Journal of Experimental Medicine·C MundtI L Mårtensson
Nov 30, 2006·The Journal of Experimental Medicine·Thomas WossningHassan Jumaa
Feb 9, 2010·International Immunology·Tomohiro Kurosaki
Feb 15, 1996·Nucleic Acids Research·Y ZhangM Reth
Jun 1, 1993·British Journal of Haematology·M DeaneJ D Norton
Apr 1, 1993·Immunological Reviews·J BorstJ J van Dongen
Apr 1, 1993·Immunological Reviews·J Jongstra, V Misener
Jun 1, 1994·Immunological Reviews·A SundbladA Coutinho
Oct 28, 2004·Science's STKE : Signal Transduction Knowledge Environment·Jacob Z Dalgaard, Sonya Vengrova
Jun 27, 2007·Molecular and Cellular Biology·Li BaiDemin Wang
Jan 1, 1997·Annual Review of Immunology·H von Boehmer, H J Fehling
Jun 1, 1992·The Journal of Clinical Investigation·J Schwaber, B Malone
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y MinegishiM E Conley
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·C E SayeghM J Ratcliffe
Jan 1, 1996·International Reviews of Immunology·E Spanopoulou
Jan 1, 1997·International Reviews of Immunology·T J Kipps
Jan 1, 1992·International Reviews of Immunology·J M Teale, C A Medina

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