The profile of melatonin production in tumour-bearing rats

Life Sciences
Ana Carolina Franco FerreiraL F Costa Rosa

Abstract

The pineal gland is involved in the regulation of tumour growth through the anticancer activity of melatonin, which presents immunomodulatory, anti-proliferative and anti-oxidant effects. In this study we measured melatonin content directly in the pineal gland, in an attempt to clarify the modulation of pineal melatonin secretory activity during tumour growth. Different groups of Walker 256 carcinosarcoma bearing rats were sacrificed at 12 different time points during 24h (12h:12h light/dark cycle) on different days during the tumour development (on the first, seventh and fourteenth day after tumour inoculation). Melatonin content in the pineal gland was determined by high-performance liquid chromatography with electrochemical detection. During tumour development the amount of melatonin secreted increased from 310.9 ng/mg of protein per day from control animals, to 918.1 ng/mg of protein per day 14 days after tumour implantation, and there were changes in the pineal production profile of melatonin. Cultured pineal glands obtained from tumour-bearing rats turned out to be less responsive to noradrenaline, suggesting the existence, in vivo, of putative factor(s) modulating pineal melatonin production. The results demonstrated tha...Continue Reading

References

Jan 1, 1988·Annals of the New York Academy of Sciences·G J MaestroniW Pierpaoli
Nov 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L JonesA C Greiner
May 12, 1994·European Journal of Pharmacology·R C CarneiroR P Markus
Jul 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P LissoniV Chatikhine
Jul 23, 1998·Physiological Reviews·J Vanecek
Mar 18, 2000·Advances in Experimental Medicine and Biology·C Bartsch, H Bartsch
Oct 18, 2000·Annals of Internal Medicine·D P Kotler
Jan 3, 2001·Medicinal Research Reviews·J M ArgilésF J López-Soriano
Dec 18, 2002·Journal of Pineal Research·Maria R RodriguesAna Campa

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Citations

Oct 28, 2015·Mediators of Inflammation·Alessio MolfinoAlessandro Laviano
Aug 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Alessandro LavianoMarilia Seelaender
Oct 26, 2007·Experimental Biology and Medicine·Aline Villa Nova BacurauReury Frank Pereira Bacurau

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