The Profile of Serum Transferrin Isoforms in Rheumatoid Arthritis

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Monika GudowskaLech Chrostek

Abstract

Transferrin, a microheterogeneous iron-transporting N-glycoprotein, is an optimal model for the analysis of the glycosylation profile in rheumatoid arthritis. The aim of this study was to assess the transferrin isoforms profile in RA patients at the time of diagnosis and then look into the associations with disease activity. Serum samples were collected from 48 patients with rheumatoid arthritis. The patients were males (6) and females (42) (age range: 33-85 years). Control group consisted of 30 healthy volunteers. Transferrin isoforms were analysed by capillary electrophoresis on MINICAP electrophoretic system. There was a significant decrease in the relative concentrations of trisialo- (mean ± SD; 2.130 ± 1.112) and pentasialotransferrin (13.562 ± 3.088), and significant increase in tetrasialotransferrin (83.640 ± 3.165) in RA patients when compared to the control group (3.615 ± 1.156; 76.840 ± 5.621; 18.610 ± 6.027, respectively) (U Mann-Whitney test: P < 0.001 for all comparisons). There were no significant changes in the disialotransferrin concentrations in RA patients. Trisialotransferrin concentration correlated with RA activity expressed as DAS 28 in RA patients (P < 0.001). The low trisialotransferrin concentration was...Continue Reading

References

Jan 1, 1987·Human Heredity·M I Kamboh, R E Ferrell
Feb 13, 2002·Arthritis and Rheumatism·Henk VisserJohanna M W Hazes
May 16, 2003·Nature·Gary S Firestein
Oct 2, 2004·Annals of the Rheumatic Diseases·E LindqvistT Saxne
Nov 3, 2007·The American Journal of Medicine·Vikas Majithia, Stephen A Geraci
Jul 27, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·François Schellenberg, Jos P M Wielders
Jun 15, 2011·Human Molecular Genetics·Zoltán KutalikJohn B Whitfield
Feb 6, 2013·Scandinavian Journal of Rheumatology·E GruszewskaS Sierakowski
Feb 10, 2017·Clinical Laboratory·Monika GudowskaLech Chrostek

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Citations

Sep 12, 2020·Journal of Clinical Medicine·Agnieszka GrytczukLech Chrostek
Jun 18, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yanqi MaSongbo Fu
Mar 13, 2020·Journal of Proteome Research·Montserrat Mancera-ArteuVictoria Sanz-Nebot

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