The profile of the epidermal growth factor system in rat endometrium during postpartum involution period

Veterinary Research Communications
E AlanHakan Sağsöz

Abstract

The epidermal growth factor (EGF) plays a crucial role in the control of uterine cell proliferation, growth and differentiation. This study was designed to investigate the spatiotemporal expression pattern and localization of the EGF receptor/ligand system during the process of uterine involution using immunohistochemistry. Our results indicated that the expression of the ErbB/HER receptors and their ligands varied with structural changes in the uterus at different days of involution. Supranuclear punctate ErbB1 immunostaining was observed in the luminal and glandular epithelial cells and endometrial fibroblasts. Moderate ErbB2/HER2 immunoreactivity was observed in the lateral membrane and cytoplasm of the epithelial cells on the 1st, 3rd and 5th days and was decreased on the other days of involution. The amount of nuclear and cytoplasmic ErbB3/HER3 and ErbB4/HER4 immunostaining remained constant throughout the postpartum period. The EGF immunoreaction was weak in the luminal and glandular epithelium throughout the involution period. Although the cytoplasmic AREG immunoreactivity in the glandular epithelium was stronger on the 1st and 3rd days compared with the other days of involution, NRG1 immunostaining was weak on the 1st a...Continue Reading

References

May 1, 1991·Human Reproduction·K SmithM C Rees
Sep 1, 1990·Molecular Reproduction and Development·Z Werb
Jul 1, 1985·Endocrinology·V R Mukku, G M Stancel
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ShoyabG J Todaro
Jan 1, 1987·Advances in Experimental Medicine and Biology·G M StancelG Verner
Sep 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R M GardnerG M Stancel
May 1, 1972·The Biochemical Journal·J N Ryan, J F Woessner
Feb 1, 1973·Biology of Reproduction·M V Clark, T H Brinsfield
Aug 1, 1972·Journal of Ultrastructure Research·P F Parakkal
Apr 16, 1996·Biochemical and Biophysical Research Communications·L MonneyC Borner
Jul 1, 1997·Molecular Reproduction and Development·E C TsarkL M Wiley
Feb 14, 1998·Journal of Reproduction and Fertility·K WollenhauptK P Brüssow
Apr 16, 1998·Journal of Reproduction and Fertility·S N LennardF Stewart
Jun 11, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R MiturskiJ A Jakowicki
Apr 6, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V V RyvniakA V Pelin
Jun 16, 1999·Molecular Reproduction and Development·C GerstenbergF Stewart
Jan 5, 2000·Molecular Reproduction and Development·Z P YueM J Harper
Jun 14, 2000·Animal Reproduction Science·R J Esslemont, M A Kossaibati
Feb 22, 2001·Biochemical and Biophysical Research Communications·Y YamanakaK Sobue
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.