The profiles of dysbiotic microbial communities

AIMS Microbiology
Paola Brun

Abstract

Alterations in the human gut microbiota play an important role in disease pathogenesis. Although next-generation sequencing has provided observational evidence linking shifts in gut microbiota composition to alterations in the human host, underlying mechanisms remain elusive. Metabolites generated within complex microbial communities and at the crossroads with host cells may be able to explain the impact of the gut microbiome on human homeostasis. Emerging technologies including novel culturing protocols, microfluidic systems, engineered organoids, and single-cell imaging approaches are providing new perspectives from which the gut microbiome can be studied paving the way to new diagnostic markers and personalized therapeutic interventions.

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Methods Mentioned

BETA
PCR
whole-genome shotgun sequencing
phosphotransferase
RNAseq
FACS
MDA
chips
biopsies
imaging techniques

Software Mentioned

RNAseq
FACS

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