PMID: 7695065Oct 1, 1994Paper

The profiles of interleukin (IL)-2, IL-6, and interferon-gamma production by peripheral blood mononuclear cells from house-dust-mite-allergic patients: a role for IL-6 in allergic disease

Allergy
S M McHughP W Ewan

Abstract

We have developed a model to measure cytokine production by peripheral blood mononuclear cells (PBMC) in vitro. In this report, we examine the production of interleukin-2 (IL-2), IL-6, and interferon-gamma (IFN-gamma) by PBMC of house-dust-mite (Dermatophagoides pteronyssinus)-allergic subjects. When stimulated with specific allergen (D. pteronyssinus), PBMC of patients produced significant levels of IL-2 and high levels of IL-6, but little or no IFN-gamma. Nonatopic control PBMC also produced IL-6, although at lower levels, but no IL-2 or IFN-gamma. A ubiquitous antigen, streptokinase/streptodornase (SKSD), induced high levels of IL-2 in patients, but only low levels of IFN-gamma and IL-6. Nonatopic controls produced similar levels of IL-2 and IL-6, but high levels of IFN-gamma to SKSD. IL-2 and IFN-gamma levels induced by the T-cell mitogen phytohaemagglutinin (PHA) were similar in patient and control groups, but IL-6 levels were significantly lower in the patients. IgE synthesis in vitro was shown only in atopic PBMC cultures stimulated with specific allergen. The major points can be summarized as 1) IL-2 production by atopic patients in response to allergen; 2) IL-6 production to allergen by both atopic and nonatopic patien...Continue Reading

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Citations

Apr 30, 1999·Allergy·G T KampenL J Petersen
Aug 17, 2001·Journal of Immunoassay & Immunochemistry·E J Pool, P Bouic
May 17, 2000·Current Opinion in Pulmonary Medicine·A A Floreani, S I Rennard
Sep 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M McHughP W Ewan
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J A WarnerJ O Warner
Apr 29, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M Wjst, S Dold
Oct 6, 1997·American Journal of Respiratory Cell and Molecular Biology·C LeonardL W Poulter
Oct 12, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C J KrcoC S David
Mar 3, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Michael SalvermoserBianca Schaub
Apr 8, 2020·ACS Pharmacology & Translational Science·Yurii SarozNatasha Lillia Grimsey

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