PMID: 37487Feb 17, 1979

The prognosis and treatment of pneumococcal meningitis in Africa. 402 cases (author's transl)

La Nouvelle presse médicale
M CadozI Diop Mar

Abstract

Over a period of 5 years (1973--1977), 1083 patients were hospitalised in the Infectious Disease Clinic of the Dakar University Hospital Centre with bacteriologically confirmed purulent meningitis. The pneumococcus was responsible in 462 cases (42.6%). Analysis of 402 records showed that 234 patients (58.2% of cases) died, 123 were completely cured (30.6%) whilst there were neurological sequelae in 45 cases (28% of the survivors). The chief factors in poor prognosis were the existence and depth of changes in conscious level, age over 20 years, a CSF cell count of less than 500 per mm3, a CSF protein level greater than 2 g per 1 and I CSF antigen level over 8 microgram per ml. From a therapeutic standpoint, the percentage mortality was similar with chloramphenicol and with penicillin G, but complete cures were statistically more frequent in the patients treated initially with chloramphenicol.

Related Concepts

Bacterial Conjunctivitis
Meningitis, Pneumococcal, Penicillin-Resistant
Cell Count, Cerebrospinal Fluid Procedure
Cerebrospinal Fluid Protein Assay
Cerebrospinal Fluid
Purulent; Meningitis
Antigen Assay
Syntomycin
Antigens, Bacterial
CARD8 wt Allele

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