PMID: 3747827Sep 1, 1986Paper

The prognosis of focal segmental glomerular sclerosis of adulthood

Medicine
Stephen M KorbetE J Lewis

Abstract

We describe 46 adults with idiopathic focal segmental glomerular sclerosis (FSGS). The mean age was 36.9 years (range, 15 to 80 years). Males represented 61%, and 65.2% were white. Hypertension was a presenting feature in 63% and 32.6% had microscopic hematuria. Twenty-nine patients had nephrotic proteinuria (greater than or equal to 3.0 g/24 h) at presentation, and 13 had renal insufficiency (serum creatinine concentration greater than 1.5 mg/dl). A mean follow-up of 59.8 months (range, 3 to 255 months) was obtained. In addition to segmental sclerosis, glomerular hyalinosis was observed in 65.3% of biopsies, and this was similar irrespective of the severity of proteinuria. Sixteen of the 29 patients with nephrotic proteinuria received prednisone therapy (60 mg/day) for at least 1 month. Three received cytotoxic agents in addition. A response to therapy was observed in 50%, 5 achieving a complete remission and 3 a partial remission. No patient with non-nephrotic proteinuria received prednisone therapy. The clinical course of each patient was evaluated based on the slope calculated by the linear regression method using the inverse of serum creatinine from the time of presentation to follow-up. Patients with non-nephrotic protein...Continue Reading

Citations

Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S Roy, F B Stapleton
Sep 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D S Milliner, B Z Morgenstern
Jan 1, 1991·International Urology and Nephrology·P C ChanM K Chan
Oct 24, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kyung Hoon PaikYong Choi
Oct 15, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Neveen A SolimanGil Chernin
Jun 1, 1996·Disease-a-month : DM·R J Glassock, A H Cohen
Jun 16, 1999·Kidney International. Supplement·E Burgess
Nov 13, 2002·Kidney International·Stephen M Korbet
Jan 1, 1997·Ryōikibetsu shōkōgun shirīzu·I Kihara
Mar 18, 2003·Current Opinion in Pediatrics·Corinne Benchimol
Aug 30, 2014·Advances in Chronic Kidney Disease·Jonathan Hogan, Jai Radhakrishnan
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·P Passerini, C Ponticelli
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M KorbetE J Lewis
Dec 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M Schwartz, S M Korbet
Mar 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M KorbetE J Lewis
Jan 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M Korbet, M M Schwartz
Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanE R Heise
Sep 1, 1988·Kidney International·W A Border
Feb 26, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Jordana B Cohen, Jonathan J Hogan
Jun 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M SchwartzR Genchi
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HaasS Coventry
Jan 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R A Rodby, M M Schwartz
Jun 3, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H YoshidaT Shimada
Oct 1, 1994·Kidney International·V D'Agati
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E AlexopoulosM Papadimitriou
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I Ichikawa, A Fogo
Feb 18, 2005·Journal of the American Society of Nephrology : JASN·Stéphan TroyanovUNKNOWN Toronto Glomerulonephritis Registry Group
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·M M SchwartzS M Korbet
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C PonticelliA Baroli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.