The prognosis of mid-range ejection fraction heart failure: a systematic review and meta-analysis

ESC Heart Failure
Saif Altaie, Wissam Khalife

Abstract

Mid-range ejection fraction is a new entity of heart failure (HF) with undetermined prognosis till now. In our systematic review and meta-analysis, we assess the mortality and hospitalization rates in mid-range ejection fraction HF (HFmrEF) and compare them with those of reduced ejection fraction heart failure (HFrEF) and preserved ejection fraction HF (HFpEF). We conducted our search in March 2018 in the following databases for relevant articles: PubMed, CENTRAL, Google Scholar, Web of Science, Scopus, NYAM, SIEGLE, GHL, VHL, and POPLINE. Our primary endpoint was assessing all-cause mortality and all-cause hospital re-admission rates in HFmrEF in comparison with HFrEF and HFpEF. Secondary endpoints were the possible causes of death and hospital re-admission. Twenty-five articles were included in our meta-analysis with a total of 606 762 adult cardiac patients. Our meta-analysis showed that HFmrEF had a lower rate of all-cause death than had HFrEF [relative risk (RR), 0.9; 95% confidence interval (CI), 0.85-0.94]. HFpEF showed a higher rate of cardiac mortality than did HFmrEF (RR, 1.09; 95% CI, 1.02-1.16). Also, HFrEF had a higher rate of non-cardiac mortality than had HFmrEF (RR, 1.31; 95% CI, 1.22-1.41). We detected a signif...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Dec 7, 2005·Circulation·Scott D SolomonUNKNOWN Candesartan in Heart Failure Reduction in Mortality (CHARM) Investigators
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Dec 9, 2010·European Heart Journal·Barry A Borlaug, Walter J Paulus
May 23, 2012·Circulation·Benjamin A SteinbergUNKNOWN Get With the Guidelines Scientific Advisory Committee and Investigators
Aug 6, 2014·The American Journal of Cardiology·Andrew H ColesRobert J Goldberg
Sep 12, 2014·European Journal of Heart Failure·Carolyn S P Lam, Scott D Solomon
Dec 25, 2016·Revista Española De Cardiología·Inés Gómez-OteroUNKNOWN Red Española de Insuficiencia Cardiaca researchers (REDINSCOR II)
Mar 21, 2017·International Journal of Cardiology·Domingo A Pascual-FigalUNKNOWN MUSIC and REDINSCOR I research groups
Apr 4, 2017·European Journal of Heart Failure·Kanako TsujiUNKNOWN CHART-2 Investigators
Sep 28, 2017·European Journal of Heart Failure·Angela S KohLars H Lund
Nov 17, 2017·Journal of the American College of Cardiology·Kevin S ShahGregg C Fonarow
Dec 12, 2017·European Journal of Heart Failure·Vijeta BhambhaniJennifer E Ho
Jan 7, 2018·International Journal of Cardiology·María Esther Guisado-EsparteroUNKNOWN RICA investigators group
Feb 6, 2018·The American Journal of Cardiology·Yasuhiro HamataniUNKNOWN Investigators for the WET-NaDEF Collaboration Project

❮ Previous
Next ❯

Citations

Dec 28, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Shin-Ichi Momomura, Miyuki Ito
Jun 27, 2020·ESC Heart Failure·Ana Belen Mendez FernandezEulàlia Roig Minguell
Jun 21, 2019·European Journal of Preventive Cardiology·Akiomi YoshihisaYasuchika Takeishi
Nov 7, 2019·Journal of Clinical Medicine·Patrick DoeblinSebastian Kelle
Apr 11, 2019·European Journal of Preventive Cardiology·George Cm SiontisLukas Hunziker
Nov 27, 2019·PloS One·Ulrich Fischer-RasokatWon-Keun Kim
Sep 23, 2020·The International Journal of Cardiovascular Imaging·Ibrahim MaraiShemy Carasso
Nov 3, 2020·Cardiac Failure Review·Davide MargonatoAndrea Mortara
Jan 13, 2021·Journal of Clinical Medicine·Eleni-Evangelia KoufouAndreas P Kalogeropoulos
Jun 12, 2021·Frontiers in Cardiovascular Medicine·Qing ZhouQingchun Zeng
Jun 25, 2021·Journal of Pharmacy Practice·Carrie BakerRiley D Bowers
Nov 7, 2021·Cardiovascular Diabetology·Antonio CerielloUNKNOWN D&CVD EASD Study Group

❮ Previous
Next ❯

Software Mentioned

SIEGLE
Scopus
Web
POPLINE
of
NYAM
REVMAN
Google Scholar
Science

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.