The Prognosis of Nail Apparatus Melanoma: 20 Years of Experience from a Single Institute

Dermatology : International Journal for Clinical and Investigative Dermatology
Emi DikaBianca Maria Piraccini

Abstract

Nail apparatus melanoma (NAM) is an uncommon tumor, especially in Caucasians. The prognosis of patients affected by NAM was analyzed and correlated with the histopathological criteria and the surgical management of the tumors. We collected data regarding NAM referred to the Skin Cancer Unit of the Dermatology Department of the University of Bologna, from 1992 to January 2012. Out of 1,327 melanoma cases diagnosed between 1992 and 2012, 42 patients were affected by NAM (2.93%). All the patients were Caucasian. Two deceased patients with insufficient medical records and 1 woman with a personal history of breast cancer were excluded. Thirty-nine cases entered this study: 24 were women (67%) and 15 men (33%). The mean age at diagnosis of NAM was 57.3 years (range 29-88 years). Statistical analyses showed that prognosis was significantly correlated with the Breslow thickness (≥/<2 mm; p = 0.02), regression (p < 0.0001) and ulceration (p = 0.04). Regarding surgical management, Kaplan-Meier's test pointed out that performing functional surgery compared to disarticulation did not correlate with a better prognosis of patients (p = 0.08). In our experience, the surgical management (disarticulation with respect to functional surgical exci...Continue Reading

Citations

Oct 4, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·E BenatiG Argenziano
May 1, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·M LambertiniE Dika
Dec 4, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S LieberherrS M Seyed Jafari
Jul 9, 2020·Oncotarget·Aneta BorkowskaPiotr Rutkowski
Mar 8, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Giulia M RavaioliAnnalisa Patrizi
Sep 20, 2020·Journal of Clinical Medicine·Aneta M BorkowskaPiotr Ł Rutkowski
Aug 30, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M StaraceB M Piraccini
May 5, 2020·The Australasian Journal of Dermatology·Matthew HowardYan Pan
Jul 24, 2020·The American Journal of Dermatopathology·Cuong V NguyenAdam I Rubin
Jan 4, 2020·Clinics in Dermatology·Connie C QiuSylvia Hsu
Feb 3, 2021·Journal of Clinical Medicine·Emi DikaMaria Concetta Fargnoli
Mar 23, 2021·Dermatologic Clinics·Junqian ZhangChristopher J Miller
Mar 23, 2021·Dermatologic Clinics·Julia O Baltz, Nathaniel J Jellinek
Oct 26, 2018·Journal of the American Academy of Dermatology·Brooke VasicekEden Lake
Jun 17, 2021·Melanoma Research·Agata JanowskaValentina Dini
Apr 1, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·S Morteza Seyed JafariRobert E Hunger

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