The prognostic and predictive role of pain before systemic chemotherapy in recurrent ovarian cancer: an individual participant data meta-analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO) of 1226 patients

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
H WoopenJ Sehouli

Abstract

Aim of this study was to analyze the impact of pain on quality of life and survival in recurrent OC patients. Raw data including the QLQ-C30 questionnaire from three phase II/III trials ("Topotecan phase III," "Hector," and "TRIAS") conducted by the North-Eastern German Society of Gynecological Oncology (NOGGO) were synthesized and analyzed using logistic and Cox regression analyses. Data on pain was available for 952 patients out of 1226. Moderate to severe pain, which was defined as pain ≥ 50 in the QLQ-C30 symptom scale, was experienced by more than one-third of patients (36.6%). A total of 31% were taking non-opioid pain medication and 16% opioids. Median age at randomization was 61 years (range 25-84). Most patients (84.7%) were diagnosed in FIGO III/IV. Pain was independent from age, FIGO stage, grading, amount of recurrences, and chemotherapy-free interval. ECOG was significantly worse in patients with pain (p < 0.001). Fatigue, nausea/vomiting, sleeping disorders, and abdominal symptoms such as loss of appetite, diarrhea, and constipation were more frequently found in patients with pain (all p < 0.001). Quality of life was significantly diminished (p < 0.001). Pain was also an independent marker for overall survival (OS...Continue Reading

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Citations

May 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Omar Abdel-RahmanJacob C Easaw
Sep 13, 2020·BMJ Supportive & Palliative Care·Jason W Boland, Michael I Bennett
Apr 22, 2021·Journal of Translational Medicine·Marco Maltoni, Romina Rossi
Jul 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Joosun ShinChristine Miaskowski

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