PMID: 920305Jan 1, 1977

The prognostic and therapeutic importance of changes in the CSF during the acute stage of brain injury

Acta neurochirurgica
H D Seitz, K Ocker

Abstract

This research deals with the gaseous and biochemical changes in the cerebrospinal fluid and their effects on the cerebral blood flow and metabolic rates in the acute stage of brain injury. The results have shown that the lactacidosis in the CSF is of importance for prognosis and therapy, because of its central position in the course of pathophysiological mechanisms after a traumatic brain injury. Thus the lactate concentration in the CSF does give early information about the further clinical course. CSF acidosis itself can be influenced in a favourable way by intrathecal therapy with sodium bicarbonate.

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Citations

Sep 3, 1998·Journal of Neurotrauma·B CondonA Wagstaff
Sep 1, 1981·Archives of Disease in Childhood·J ErossD Dorman
Mar 28, 2001·Journal of Clinical Pharmacology·P J WilliamsA W Fox
Jul 1, 1984·Journal of Neurosurgery·M J RosnerD P Becker
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Related Concepts

Acid-Base Imbalance
Carbonic Acid Ions
Mild Traumatic Brain Injury
Carbon Dioxide
Lactates
Dioxygen

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