PMID: 9541184Apr 16, 1998Paper

The prognostic contribution of estrogen and progesterone receptor status to a modified version of the Nottingham Prognostic Index

Breast Cancer Research and Treatment
K CollettB O Maehle

Abstract

The aim of this study was to test the prognostic contribution of estrogen (ER) and progesterone (PgR) receptor status to an index consisting of the number of positive lymph nodes, the mean nuclear area of the breast cancer cells (MNA), and tumour diameter. This index is compared with a Danish index, which includes the same factors but uses histological grade instead of MNA. The Danish index has been developed from the Nottingham Prognostic Index (NPI). In the present study of 1629 breast cancer patients the Cox proportional hazard method is used to examine the time-dependency of the index, and to test for interaction between the index and the hormone receptors. The index sorts the patients into groups with low, intermediate, and high risk of dying. Logistic regression analysis is used to report the sensitivity and specificity of the index with and without ER and PgR. Our index gave information comparable to that of the Danish group. However, the information given by our index is time-dependent, its strength being weaker after 5-year of follow-up. PgR and ER add information to high risk patients, but only in the first 5-year period. High risk patients with positive hormone receptors have a prognosis similar to intermediate risk ...Continue Reading

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Citations

Feb 5, 2004·The Breast : Official Journal of the European Society of Mastology·A SidoniE Bucciarelli
Mar 4, 2003·Breast Cancer Research and Treatment·Kenneth R HessGabriel N Hortobagyi
Dec 27, 2005·Annals of Surgical Oncology·Ronan A CahillR Gordon Watson
Apr 6, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G D'Eredita'F Ferrarese
Jul 17, 2008·Breast Cancer Research and Treatment·Olivier BrouckaertPatrick Neven
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gaynor J BatesAlison H Banham
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vanya Van BellePatrick Neven
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