The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation

Journal of Biomedical Science
Yaghoub YazdaniZeinab Zekavatian

Abstract

PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development. In this study, we investigated the effect of miR-21 and promoter methylation on the PTEN expression status in CRC tissues and analyzed association of the PTEN expression status with clinicopathological features in patients with CRC. The PTEN expression was positively detected in 67.2 % CRC tissues and all adjacent non-cancerous samples. PTEN mRNA level was negatively correlated with miR-21 level (r = -0.595, P < 0.001). PTEN expression was also correlated directly with the PTEN mRNA level (r = 0.583, P < 0.001) and conversely with miR-21 level (r = -0.632, P < 0.001). PTEN Promoter methylation was significantly associated with PTEN expression status (p = 0.013). PTEN expression was negatively associated with tumor size (p = 0.007) and advanced tumor stage (P = 0.011). Multivariate analysis indicated that tumor stage, tumor differentiation and PTEN expression status were independent prognostic factors for overall carcinoma in CRC patients (P < 0.05). The Kaplan-Meier curve indicated a negative correlation between PTEN expression levels a...Continue Reading

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Citations

Jul 18, 2017·International Journal of Molecular Sciences·Ingrid GarajováGiovanni Brandi
Apr 20, 2018·Advanced Pharmaceutical Bulletin·Mandana RastegarTouraj Farazmandfar
Oct 15, 2018·Journal of Cellular Physiology·Amirhossein BahreyniSeyed Mahdi Hassanian
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Apr 23, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Iman AkhlaghipourMeysam Moghbeli

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Methods Mentioned

BETA
light microscopy
PCR

Software Mentioned

BLAST
SPSS
Gene Runner

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