The prognostic impact of functional imaging with (123)I-mIBG in patients with stage 4 neuroblastoma >1 year of age on a high-risk treatment protocol: results of the German Neuroblastoma Trial NB97

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Matthias SchmidtF Berthold

Abstract

(123)I-meta-iodobenzylguanidine ((123)I-mIBG) scintigraphy is well established for staging and evaluation of response in children with high-risk neuroblastoma but its prognostic value in highly intensive first-line treatment protocols is uncertain. The presence of any (123)I-mIBG positive tumour tissue was correlated with event-free survival (EFS) and overall survival (OS). The prognostic impact of residual (123)I-mIBG uptake into the primary tumour and metastases for predicting outcome in 113 stage 4 neuroblastoma patients >1 year of the German Neuroblastoma Trial NB97 was assessed using a univariate log-rank test and multivariate Cox regression analysis. All patients had (123)I-mIBG positive disease at initial staging. After four courses of induction chemotherapy, 71% of patients were still (123)I-mIBG positive for the primary tumour and 61% for metastases. After six courses, 39% of patients had (123)I-mIBG uptake by the primary tumour and 45% residual (123)I-mIBG positive metastatic disease. The (123)I-mIBG status of the primary tumour site had no bearing on outcome. Residual (123)I-mIBG positive metastatic disease after four (3-y-EFS 25.7+/-5.3% versus 55.9+/-7.6%, p=0.009; 3-y-OS 49.8+/-6.1% versus 65.0+/-7.3%; p=0.021) an...Continue Reading

References

Aug 3, 1974·British Medical Journal·L M Wilson, G J Draper
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N AdyL Manil
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian H KushnerNai-Kong V Cheung
Mar 27, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Pierre OlivierJeannette van Velzen
Jan 22, 2005·Current Opinion in Pediatrics·John M Maris
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ruediger SpitzFrank Berthold
Jul 11, 2006·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thorsten SimonFrank Berthold
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·André OberthuerMatthias Fischer

❮ Previous
Next ❯

Citations

Nov 16, 2012·Pediatric Radiology·Wolfgang Peter MuellerThomas Pfluger
Jan 9, 2009·European Journal of Nuclear Medicine and Molecular Imaging·O SchoberB Riemann
Feb 25, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ferdinand SudbrockHarald Schicha
Jun 19, 2010·The New England Journal of Medicine·John M Maris
May 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine K MatthayAlice L Yu
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian H KushnerNai-Kong V Cheung
Aug 8, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nai-Kong V CheungShakeel Modak
Jul 26, 2011·AJR. American Journal of Roentgenology·Daniel Y Lee, King C P Li
Apr 22, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mark P S Dunphy, Jason S Lewis
Jul 27, 2012·Future Oncology·Jennifer GainsMark Gaze
May 28, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Henriette Ingrid MelzerThomas Pfluger
Sep 24, 2014·International Journal of Radiation Oncology, Biology, Physics·Ali MazloomArnold C Paulino
Nov 12, 2014·Annual Review of Medicine·Chrystal U Louis, Jason M Shohet
Oct 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Brian H KushnerNai-Kong V Cheung
Apr 14, 2016·Seminars in Nuclear Medicine·Marguerite T ParisiGregory A Yanik
Jan 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rochelle BagatellJed Nuchtern
Jan 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Boris DecarolisMatthias Schmidt
May 5, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R ParkDominique Valteau-Couanet
Apr 11, 2018·Nature Reviews. Cancer·Jamie I FletcherMurray D Norris
Jun 26, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Zvi Bar-SeverFrancesco Giammarile
Dec 21, 2012·Pediatric Blood & Cancer·Julie R ParkUNKNOWN COG Neuroblastoma Committee
Mar 27, 2015·Pediatric Blood & Cancer·Nehal S ParikhUNKNOWN International Society of Pediatric Oncology
Jun 1, 2012·Critical Reviews in Clinical Laboratory Sciences·Cormac Owens, Meredith Irwin
Dec 14, 2011·Pediatric Blood & Cancer·Rani E GeorgeLisa Diller
Aug 5, 2018·Indian Journal of Pediatrics·Yu-Tong ZhangZi-Ling Liu
Jun 29, 2010·Pediatric Hematology and Oncology·Robin WachowiakRegine Kluge
Jul 21, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alberto GaraventaRiccardo Haupt
Mar 31, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·J Van HeerdenA Brink
Feb 27, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gregory A YanikKatherine K Matthay
Mar 23, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nikolaos D PapathanasiouJamshed B Bomanji
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Neeta Pandit-Taskar, Shakeel Modak
Sep 10, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gregory A YanikKatherine K Matthay
Jul 28, 2021·Expert Review of Clinical Pharmacology·Stefano MastrangeloAntonio Ruggiero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

© 2022 Meta ULC. All rights reserved