PMID: 12754622May 20, 2003Paper

The prognostic impact of hormone receptors and c-erbB-2 in pregnancy-associated breast cancer and their correlation with BRCA1 and cell cycle modulators

International Journal of Surgical Pathology
W ReedJ M Nesland

Abstract

A population-based series of 122 patients with pregnancy-associated breast carcinomas was histologically revised and the relationship between hormone receptors, c-erbB-2, BRCA1, p27, cyclin E, and cyclin D1 was studied. The 5-year overall survival was 41%; 70% had tumor size >20 mm; 72% had metastasized to regional lymph nodes; 95% were histologic grade II or III; 66% and 75% were negative for estrogen and progesterone receptor, respectively; and c-erbB-2 expression was high (44%). BRCA1 expression was reduced in 33% of the cases. The expression of p27, cyclin D1, and cyclin E was low, 11%, 9%, and 16%, respectively. Cyclin D1 was positively associated with the hormone receptors (p< or =0.01). In multivariate analysis, lymph node status, progesterone receptor, and c-erbB-2 were significant prognostic factors. In subdividing the group according to lymph node status, c-erbB-2 and progesterone receptor retained a prognostic significance in the node positive group only. In conclusion, pregnancy-associated breast carcinomas are aggressive tumors, with low expression of hormone receptors, BRCA1, p27, and cyclin E and D1, and high expression of c-erbB-2.

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Citations

Dec 25, 2008·Breast Cancer Research and Treatment·Alexandra ShayeIsabelle Bedrosian
May 15, 2013·Breast Cancer Research and Treatment·Xiao-Ling XuWei-Min Mao
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Gilbert H Smith
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Oct 6, 2020·Frontiers in Oncology·Anna-Maria KorakitiFlora Zagouri

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