The Prognostic Impact of Intraductal Carcinoma of the Prostate: A Systematic Review and Meta-Analysis

The Journal of Urology
Noriyoshi MiuraShahrokh F Shariat

Abstract

This systematic review and meta-analysis aimed to assess the prognostic impact of intraductal carcinoma of the prostate in patients with prostate cancer. A systematic search was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis statement. We searched PubMed®, Web of Science™, the Cochrane Library and Scopus® up to October 2019. The end points were biochemical recurrence-free, cancer specific and overall survival. We identified 32 studies with 179,766 patients. A total of 31 studies containing 179,721 patients with localized and advanced prostate cancer were eligible for meta-analysis. In localized prostate cancer intraductal disease was associated with adverse outcomes including lower biochemical recurrence-free survival (pooled HR 2.09, 95% CI 1.75-2.50) and cancer specific survival (pooled HR 2.93, 95% CI 2.25-3.81). In advanced prostate cancer overall survival was lower in patients with vs without intraductal disease (pooled HR 1.75, 95% CI 1.43-2.14). Subgroup analysis by specimen type revealed that intraductal carcinoma of the prostate is a significant negative prognostic factor in both biopsies and prostatectomy specimens. Moreover, subgroup analyses based on the histopathologica...Continue Reading

Citations

May 16, 2021·Advances in Anatomic Pathology·Murali Varma
Jun 2, 2021·The Journal of Molecular Diagnostics : JMD·Daniela C SallesTamara L Lotan
Jul 16, 2021·The American Journal of Surgical Pathology·Hemamali SamaratungaLars Egevad

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