The prognostic impact of the mediastinal fat tissue invasion in patients with non-small cell lung cancer.

General Thoracic and Cardiovascular Surgery
N CitakA Sayar

Abstract

The prognosis of the mediastinal fat tissue invasion in non-small cell lung cancer (NSCLC) patients has not yet been clearly defined. The present study aimed to investigate the prognostic impact of the mediastinal fat tissue invasion in NSCLC patients. We analyzed 36 patients who were found mediastinal fat tissue invasion by pathological evaluation (mediastinal fat group) and 248 patients who were classified as T4-NSCLC according to the 8th TNM classification (T4 group; invasion of other mediastinal structures in 78 patients, ipsilateral different lobe satellite pulmonary nodule in 32 patients, and tumor diameter > 7 cm in 138 patients). Resection was regarded as complete (R0) in 255 patients (89.7%). Mediastinal fat group showed significantly higher incidence of incomplete resection (R1) and more left-sided tumors than the T4 group (p = 0.01, and p = 0.002, respectively). The survival was better in T4 group than mediastinal fat group (median 57 months versus 31 months), although it was not significant (p = 0.205). Even when only N0/1 or R0 patients were analyzed, the survival was not different between two groups (p = 0.420, and p = 0.418, respectively). 5-year survival rates for T4 subcategories (invasion of other structures, ...Continue Reading

References

Jun 26, 2007·The Annals of Thoracic Surgery·Kazumichi YamamotoFumitsugu Kojima
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Oct 30, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Leslie Eisenbud Quint
Jan 24, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Leslie E Quint
Jul 22, 2008·The Annals of Thoracic Surgery·Farhood FarjahDavid R Flum
Jul 9, 2009·Chest·Frank C DetterbeckLynn T Tanoue
Aug 31, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hajime OtsukaAtsushi Ochiai
Dec 7, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yasuhiro SakaiUNKNOWN Hyogo Cancer Center - Kobe University Hospital Lung Cancer Research Group
Feb 14, 2012·General Thoracic and Cardiovascular Surgery·Adnan SayarAtilla Gürses
Jul 31, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kelly J Butnor, William D Travis
Apr 24, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shun-ichi WatanabeUNKNOWN Japanese Joint Committee of Lung Cancer Registry
May 15, 2015·The Indian Journal of Radiology & Imaging·Nilendu C Purandare, Venkatesh Rangarajan
Jan 15, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Particip
Jul 11, 2018·Journal of Cardiothoracic Surgery·Yuki TakahashiAtsushi Watanabe
Dec 7, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Qiuyuan LiGening Jiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.