The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jeanny KwonJihye Cha

Abstract

We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define a high-risk group using prognosticators for recurrence. A multicenter retrospective study was conducted using the data from 13 Korean institutions from 2000 to 2010. A total of 249 IB-IIA patients with high-risk factors were included. We evaluated distant metastasis-free survival (DMFS) and disease-free survival (DFS) in relation to clinicopathologic factors including pNstage, number of mPLN, lymph node (LN)ratio (number of positive LN/number of harvested LN), and log odds of mPLNs (log(number of positive LN+0.5/number of negative LN+0.5)). In univariate analysis, histology (squamous cell carcinoma [SqCC] vs. others), lymphovascular invasion (LVI), number of mPLNs (≤ 3 vs. > 3), LN ratio (≤ 17% vs. > 17%), and log odds of mPLNs (≤ ‒0.58 vs. > ‒0.58) were significant prognosticators for DMFS and DFS. Resection margin involvement only affected DFS. No significant survival difference was observed between pN0 patients and patients with 1-3 mPLNs. Multivariate analysis revealed that mPLN > 3, LVI, and non-SqCC were unf...Continue Reading

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Citations

Nov 7, 2019·Archives of Gynecology and Obstetrics·P WidschwendterT W P Friedl
Aug 20, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFrancesco Raspagliesi
Jun 10, 2020·Cancer Cell International·Shuhang QinShuzhong Yao
Mar 26, 2021·The Journal of Obstetrics and Gynaecology Research·Cigdem KilicTaner Turan
Sep 5, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Max PetersUNKNOWN EMBRACE Collaborative Group

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Methods Mentioned

BETA
hysterectomy
dissection

Software Mentioned

R

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