PMID: 7543077Jul 28, 1995Paper

The prognostic influence of neuroendocrine cells in prostate cancer: results of a long-term follow-up study with patients treated by radical prostatectomy

International Journal of Cancer. Journal International Du Cancer
M A NoordzijF H Schröder

Abstract

The distribution of immunohistochemically defined neuroendocrine (NE) cells in benign, pre-cancerous and neoplastic prostatic tissues and the prognostic value of these cells in prostate cancer were studied in the radical prostatectomy specimens of 90 patients from whom complete long-term follow-up data were available. The tissue blocks containing all the different Gleason patterns observed in a particular tumor were selected and immunostained. Since chromogranin B stained only a few cells compared to chromogranin A (CgA), NE cells were only defined by their reactivity with CgA. A semi-quantificative CgA score was assessed for all distinct pathological areas. Cox's regression model was used to analyze the influence of final TNM classification (TNM, 1992), Gleason sum score (GSS), age and CgA score on the probability of progression and tumor-specific death. NE cells were demonstrated in all normal prostatic tissues and in most hyperplastic and intra-epithelial neoplastic lesions. CgA staining was seen in 78% of the tumors. CgA scores were not related with Gleason growth patterns, GSS or TNM classification and had no prognostic value. The independent prognostic variables in Cox's regression model were: GSS and pT stage for progres...Continue Reading

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Citations

Apr 30, 1999·The Prostate·P A Abrahamsson
Feb 10, 1998·International Journal of Cancer. Journal International Du Cancer·C FestucciaM Bologna
Sep 1, 2005·Der Pathologe·C G SauerR Grobholz
Aug 25, 2004·The Breast : Official Journal of the European Society of Mastology·C van KrimpenM Menke
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Mar 29, 2002·Microscopy Research and Technique·Alfonso CalvoLuis Montuenga
Nov 1, 2011·Clinical Genitourinary Cancer·Levent SagnakHamit Ersoy
Aug 2, 2011·Urologic Oncology·Kouhei NishikawaYoshiki Sugimura
Dec 1, 2008·Surgical Pathology Clinics·Samson W Fine
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Jan 22, 2005·European Urology·Nadezda Vashchenko, Per-Anders Abrahamsson
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May 21, 2011·International Journal of Radiation Oncology, Biology, Physics·Daniel J KraussAlvaro A Martinez

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