The prognostic legacy of left ventricular hypertrophy: cumulative evidence after the MAVI study

Journal of Hypertension
Fabio AngeliMAVI Investigators

Abstract

Although regression of left ventricular hypertrophy (LVH) confers a marked prognostic benefit, it is unknown whether cardiovascular risk in these patients is comparable to those who never developed LVH. We analyzed the 'Massa Ventricolare sinistra nell'Ipertensione' (MAVI) study, a prospective study in which serial changes in left ventricular mass at echocardiography were associated with subsequent cardiovascular events. We also conducted a cumulative meta-analysis in order to investigate how evidence progressed in this field. We defined three phenotypes: persistently normal left ventricular mass; LVH regression; persistence/new development of LVH. Left ventricular mass was measured at baseline and 2 years after the initial assessment in 374 patients (64% women). Clinical outcomes were ascertained after the 2-year echocardiographic evaluation (mean follow-up 3.2 years). Persistence or new development of LVH was associated with an increased risk of cardiovascular events (odds ratio 1.96, 95% confidence interval 1.07-3.57, P = 0.029). In a cumulative meta-analyses that included MAVI and six comparable studies for a total of 2954 patients and 339 cardiovascular events, when a persistently normal left ventricular mass was taken as ...Continue Reading

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Citations

Feb 17, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Marios K GeorgakisEleni Th Petridou
May 10, 2016·Expert Review of Cardiovascular Therapy·Dana Cramariuc, Eva Gerdts
Nov 15, 2017·American Journal of Hypertension·Fabio AngeliGianpaolo Reboldi
Jun 4, 2021·Current Cardiology Reports·Ramachandran S VasanVanessa Xanthakis

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MAVI
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