The prognostic relevance of node metastases in optimally cytoreduced advanced ovarian cancer

Journal of Cancer Research and Clinical Oncology
Cornelia BachmannEva-Maria Grischke

Abstract

To delineate the relevance of pelvic and para-aortic node involvement in optimally cytoreduced (residual tumour <1 cm) stage IIIC ovarian cancer patients. Ninety-five consecutive optimally cytoreduced (R ≤ 1 cm) patients with primary stage IIIc ovarian cancer underwent stage-related surgery and got adjuvant platinum-based chemotherapy. Median follow-up: 53.5 months. All patients got systematic lymphadenectomy. On average, 24.7 pelvic and para-aortic lymph nodes were removed per patient (range 1-60 nodes). Patients were stratified into three groups to evaluate node involvement (ratio: affected to resected nodes): (1) (=0); (2) (>0-≤ 0.5) >0 and ≤ 50 % of affected nodes; (3) (>0.5-≤ 1) >50 % of affected nodes. Clinical parameters were retrospectively evaluated. Kaplan-Meier survival curve was used to evaluate the prognostic value. Most often serous histology, histologic grade 3 and a node ratio >0-≤ 0.5 (61.1 %) were detected. Complete cytoreduction (R = 0 mm) has significant best prognostic impact compared to R > 0 mm-1 cm (OS: p = 0.047, PFS: p = 0.00). Node involvement was associated with serous histology and grade 3. Increasing node ratio leads to significant decreased OS (p = 0.019) and significant best OS was associated wit...Continue Reading

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Citations

Mar 24, 2016·International Journal of Surgery·Juan ZhouFeng-Yan Li
Jun 12, 2020·Indian Journal of Surgical Oncology·Mohamed Ibrahim FahimRasha Mahmoud Allam
Mar 20, 2019·Open Medicine·Xiaoxia TongYuan Xu
Nov 4, 2020·Minerva ginecologica·Pawel MachPaul Buderath

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