The Prognostic Role of Circulating Tumor Cells (CTCs) in Lung Cancer

Frontiers in Oncology
Joanna KapelerisChamindie Punyadeera

Abstract

Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting.

References

Jan 1, 1990·Cytometry·S MiltenyiA Radbruch
Mar 4, 2000·Journal of Pain and Symptom Management·M E Cooley
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert T KrivacicRichard H Bruce
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Mar 26, 2005·Thorax·S S Birring, M D Peake
Mar 7, 2006·Cancer·Kenneth R HessJames L Abbruzzese
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Jul 29, 2008·International Journal of Cancer. Journal International Du Cancer·Wei HePhilip S Low
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·AmirAli H TalasazRonald W Davis
Feb 28, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lecia V SequistThomas J Lynch
Jan 15, 2010·Current Opinion in Genetics & Development·Shyamala Maheswaran, Daniel A Haber
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Antoine-Emmanuel SalibaJean-Louis Viovy
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henry K LinRichard J Cote
Oct 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shannon L StottMehmet Toner
Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Véronique HofmanPaul Hofman
Feb 9, 2011·The Journal of Cell Biology·Min YuDaniel A Haber
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Robert R Langley, Isaiah J Fidler
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew G KrebsFiona H Blackhall
Apr 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T HristozovaI Tinhofer
Aug 9, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·L A DevrieseJ H M Schellens
Nov 8, 2011·Clinics in Chest Medicine·Charles S Dela CruzRichard A Matthay
Nov 8, 2011·Clinics in Chest Medicine·Jill E Larsen, John D Minna
Dec 17, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthew G KrebsCaroline Dive
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian-Mei HouCaroline Dive
Jan 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tateaki NaitoNobuyuki Yamamoto
Jan 21, 2012·Journal of Thoracic Disease·Peter M Ellis, Rachel Vandermeer
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Feb 7, 2012·Physical Biology·Peter Kuhn, Kelly Bethel
Feb 7, 2012·Physical Biology·Dena MarrinucciPeter Kuhn
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Apr 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth A PunnooseMark R Lackner
Apr 25, 2012·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Catherine Alix-Panabières
Jun 13, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T J N HiltermannH J M Groen
Jun 28, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M IlieP Hofman
Sep 28, 2012·Clinical Chemistry·Catherine Alix-Panabières, Klaus Pantel

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Citations

Nov 5, 2019·Expert Review of Molecular Diagnostics·Arutha KulasingheChamindie Punyadeera
Mar 1, 2019·Cancers·Véronique HofmanPaul Hofman
Mar 8, 2020·Archives of Gynecology and Obstetrics·Malgorzata Banys-PaluchowskiGerhard Gebauer
Jul 16, 2019·Expert Review of Molecular Diagnostics·Marianna GalloNicola Normanno
May 30, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P ZhangT Feng
Jun 23, 2019·Science Immunology·Mariaelvy BianchiniRemco T A Megens
Aug 14, 2019·Cells·Dada Oluwaseyi TemilolaLuiz Fernando Zerbini
Oct 1, 2020·Pharmaceuticals·Connor O'LearyKen J O'Byrne
Sep 13, 2020·Nature Reviews. Clinical Oncology·Charu AggarwalDavid R Gandara
Dec 29, 2020·Laryngoscope Investigative Otolaryngology·Ethan J HarrisJochen Lorch
Oct 14, 2020·Translational Oncology·Vinitha RichardRadhakrishna M Pillai
Nov 2, 2019·Hematology/oncology Clinics of North America·Bo SunAndrew Z Wang
May 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Steven De MichinoScott V Bratman
May 4, 2021·Frontiers in Oncology·Cláudia FreitasVenceslau Hespanhol
Jun 22, 2021·Frontiers in Oncology·Hongyi ZhangFengfeng Cai
May 19, 2021·Cold Spring Harbor Perspectives in Medicine·Humam KadaraKostyantyn Krysan

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Methods Mentioned

BETA
biopsies
biopsy
blood draw
Assay
Chip
xenograft
xenografts

Software Mentioned

Cellsearch

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