The Prognostic Role of Peripheral Lymphocyte Subsets in Patients With Acute Pancreatitis

The American Journal of the Medical Sciences
Ziqiang ZhaoJiaqing Shen

Abstract

The prognostic role of peripheral lymphocyte subsets in early stage of acute pancreatitis (AP) is unknown. After enrollment, blood samples were collected in the first 24 hours of the onset of AP in 164 patients. The lymphocyte count and the percentage of CD3+, CD3+CD4+, CD3+CD8+, CD3-CD19+and CD3-CD (16 + 56)+ cells were assessed. Reduction of the lymphocyte count and the percentage of CD3+CD8+ and CD3-CD (16 + 56)+ cells within 24 hours of the onset of AP as well as an increase in the percentage of CD3+ and CD3+CD4+ cells were observed. The percentage of CD3-CD (16 + 56)+ cells had the highest accuracy in prediction of AP severity. Marked changes of the percentages of lymphocyte subset were found in peripheral blood in the early stage of AP. The percentage of CD3-CD (16 + 56)+ cells in peripheral blood could be a potent prognostic predictor.

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Citations

Apr 17, 2020·Frontiers in Cellular and Infection Microbiology·Lili DingPujun Gao

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