PMID: 12788181Jun 6, 2003Paper

The prognostic significance of Gleason Grade in patients treated with permanent prostate brachytherapy

International Journal of Radiation Oncology, Biology, Physics
Louis PottersM W Kattan

Abstract

To assess the difference in biochemical freedom from relapse (BFR) between patients with clinically localized prostate cancer having Gleason Grade (GG) 3 + 4 vs. 4 + 3 disease treated with permanent prostate brachytherapy (PPB). One thousand twenty-nine consecutive T1/T2 patients underwent PPB with Gleason sum 6, 7, or 8 adenocarcinoma of the prostate. Treatment consisted of transperineal ultrasound-guided implant as monotherapy or in combination with external beam radiation and/or neoadjuvant androgen ablation (NAAD). The Kattan modification of the ASTRO consensus definition that censors patients with rising follow-up PSA values early was used to measure BFR. Kaplan-Meier actuarial survival was calculated and compared using the log-rank test. Cox proportional hazards regression was performed to assess the role of Gleason grade, initial PSA value, stage, the addition of external beam radiotherapy, and the addition of NAAD. The median follow-up for all 1029 patients is 46 months (range: 3-108 months) with a BFR at 5 years of 78.2% and at 7 years of 76.2%. The 7-year BFR for patients with GG 3 + 3 was 81.8%, GG 3 + 4 was 78.4%, GG 4 + 3 was 56.7%, and GG 4 + 4 was 50.7% (p < 0.0001). Cox regression analysis identified that the Gl...Continue Reading

References

Feb 11, 1998·International Journal of Radiation Oncology, Biology, Physics·B R PrestidgeW S Bice
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·S NagR Nath
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·C M ChaS Leibel
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Dec 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J C BlaskoW Cavanagh
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·M W KattanL Potters
May 9, 2001·The Journal of Urology·P L RossM W Kattan
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·P D GrimmW Cavanagh

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Citations

Mar 8, 2007·World Journal of Urology·Martin Burchardt, Hartwig Huland
Dec 26, 2009·Japanese Journal of Radiology·Manabu AokiChihiro Kanehira
Apr 7, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicholas P MunroAnn M Henry
Oct 31, 2008·International Journal of Radiation Oncology, Biology, Physics·Michael J BurdickJay P Ciezki
Jul 25, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshikazu OkaneyaNoriko Hosaka
Nov 22, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro KimuraShin Egawa
Aug 9, 2011·International Journal of Radiation Oncology, Biology, Physics·Felix Y FengDaniel A Hamstra
Feb 14, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christopher HerbertIngrid Spadinger
Feb 3, 2004·Journal of Cellular Biochemistry·T J FitzGeraldJoshua Meyer
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Frank PeinemannStefan Sauerland

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