PMID: 8954143Oct 1, 1996Paper

The prognostic significance of immune changes in patients with renal cancer, melanoma and colorectal cancer, treated with interferon alpha 2b

Cancer Immunology, Immunotherapy : CII
N TsavarisM Papamichael

Abstract

In the present study we evaluated the response rate and the immunorestorative properties of interferon alpha 2b (IFn alpha 2b) administered to patients with advanced renal cell carcinoma (RCC), melanoma (MEL) or colorectal cancer (CC). We studied the immune status and correlated it with clinical responses. Thirty-five patients with advanced RCC, and 14 with MEL were treated with recombinant INF alpha 2b. The dose was increased progressively from 5 x 10(6) IU/day in the first week (three times every week) to 10 x 10(6) IU/day in the second week and thereafter to 15 x 10(6) IU/day subcutaneously. In patients with CC INF alpha 2b was given at 5 x 10(6) IU/day every other day (three times every week); these patients also received (together with INF) leucovorin 200 mg m-2 day-1 in a 1-h i.v. infusion every week, and mid-infusion 400 mg/m2 5-FU was administered as an intravenous bolus every week. The response rate was as follows: for RCC, 6 patients achieved partial response (PR), 10 stable disease (SD), and 21 progressed (PD); for MEL, 5 patients achieved PR and 9 PD; for CC, 6 achieved PR, 5 SD, and 9 PD. In all patients blood was withdrawn prior to INF alpha 2b treatment and then monthly. T lymphocytes, after isolation from periph...Continue Reading

Citations

Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M Kirkwood
Mar 20, 2002·Cytokine & Growth Factor Reviews·Filippo BelardelliJohn M Kirkwood
Sep 6, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ene T RaigWilliam E Carson
Feb 12, 2014·Dermatology Research and Practice·Aimen Ismail, Nabiha Yusuf
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May 29, 2007·Biochimie·Maria FerrantiniFilippo Belardelli
Jun 27, 2002·British Journal of Cancer·N TsavarisD Boulamatsis
Jan 8, 2020·Scandinavian Journal of Immunology·Paolo Vidal
Mar 18, 2011·The Journal of Bone and Joint Surgery. American Volume·Tadahiko KuboMitsuo Ochi
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Jul 9, 2020·Immunotherapy·Mohadeseh Haji AbdolvahabLeila Farahmand
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