PMID: 7336150May 1, 1981Paper

The prognostic significance of in vitro bone marrow growth pattern in acute non-lymphocytic leukaemia

Scandinavian Journal of Haematology
A GustavssonH Sigurdardottir

Abstract

The growth pattern of bone marrow cells in agar culture was studied in 56 patients with untreated acute non-lymphocytic leukaemia. 4 different growth patterns were recognized: (A) colony and cluster formation, (B) growth of small clusters (3-20 cells) only but less than 600/10(5) cells, (C) growth of small clusters only but more than 600/10(5) cells, and (D) no growth in vitro. Patients in group A and B had a significantly higher remission rate (23/34) than patients in group C and D (3/22). This was true also when only patients below 60 years of age were considered. The median survival time of patients in group A and B was 7.3 months and 9.4 months, and in group C and D 4.0 months and 3.3 months. Identical growth patterns were found for marrow and blood cells in 21 of 27 patients studied and the number of clusters in blood and marrow showed a significant correlation (r = +0.96, P less than 0.001). The mean 3H-labelling index (LI) of myeloblasts determined in 32 patients was 14.8 +/- 7.8% (SD). Patients with LI below 15% tended to have a higher remission rate than patients with LI above 15%. It is concluded that the in vitro growth pattern at diagnosis of bone marrow cells from patients with ANLL is of value in detecting patient...Continue Reading

References

May 1, 1977·Scandinavian Journal of Haematology·S Knudtzon
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Citations

Jan 1, 1987·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·C Y LiG X Sun
Apr 1, 1984·Scandinavian Journal of Haematology·A GustavssonI Olsson

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