The Prognostic Significance of Pretreatment Hematologic Parameters in Patients Undergoing Resection for Colorectal Cancer

American Journal of Clinical Oncology
Margaret M KozakDaniel T Chang

Abstract

The prognostic value of several hematologic parameters, including platelet, lymphocyte, and neutrophil counts, has been studied in a variety of solid tumors. In this study, we examined the significance of inflammatory markers and their prognostic implications in patients with colorectal cancer (CRC). Patients with stage I-III CRC who underwent surgical resection at the Stanford Cancer Institute between 2005 and 2009 were included. Patients were excluded if they did not have preoperative complete blood counts performed within 1 month of surgical resection, underwent preoperative chemotherapy or radiation, had metastatic disease at diagnosis, or had another previous malignancy. We included 129 eligible patients with available preoperative complete blood counts in the final analysis. A preoperative neutrophil-to-lymphocyte ratio of>3.3 was significantly associated with worse disease-free (DFS) and overall survival (OS) (P=0.009, 0.003), as was a preoperative lymphocyte-to-monocyte ratio of ≤2.6 (P=0.01, 0.002). Preoperative lymphopenia (P=0.002) was associated with worse OS but not DFS (P=0.09). In addition, preoperative thrombocytosis was associated with worse DFS (P=0.006) and OS (P=0.010). Preoperative leukocytosis was associat...Continue Reading

References

Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·Y ShoenfeldJ Pinkhas
Jul 1, 1997·The Journal of Pathology·K M RopponenV M Kosma
Sep 6, 2000·Journal of Internal Medicine·H KuperD Trichopoulos
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 3, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Robert M StrieterJohn A Belperio
Mar 28, 2007·International Journal of Surgery·Emily J CookNeil J Keeling
Apr 24, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K J HalazunJ P A Lodge
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Feb 3, 2009·The Journal of Thoracic and Cardiovascular Surgery·Khaled M SarrafEric Lim
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanne Krogh JensenHans von der Maase
Aug 6, 1881·British Medical Journal·R Virchow
May 25, 2012·Journal of Surgical Oncology·Mitsuru IshizukaKeiichi Kubota
Jun 27, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R CarruthersA C McDonald
Sep 11, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S MallappaS J D Chadwick
Dec 19, 2013·International Journal of Cancer. Journal International Du Cancer·Joanna SzkanderaMartin Pichler

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Citations

Dec 15, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hyun MoonSang Yoon Kim
Aug 16, 2017·World Journal of Gastrointestinal Oncology·Özgür AkgülMesut Tez
Apr 3, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C PedrazzaniA Guglielmi
Mar 15, 2019·International Journal of Cancer. Journal International Du Cancer·Markus DiefenhardtUNKNOWN German Rectal Cancer Study Group
Apr 12, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Demétrius Eduardo GerminiJaques Waisberg
Sep 21, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·José Manuel Navarro RodríguezMiguel Ángel Morcillo Ródenas
Sep 3, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Nigel P MurraySocrates Aedo

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